Table 3

A1c variability and HRH risk in 1-year and 3-year follow-up periods*

Model†1-year (n=375 519)3-year (n=308 241)
OR (95% CI)P valueOR (95% CI)P value
Model 1
 A1c coefficient of variation (%) (ref <4)
  4–5.91.10 (0.92 to 1.31)0.2861.20 (1.06 to 1.35)0.003
  6–9.41.12 (0.94 to 1.33)0.2011.35 (1.20 to 1.52)<0.001
  9.5–661.33 (1.12 to 1.58)0.0011.48 (1.31 to 1.67)<0.001
Model 2
 A1c SD (ref <0.25)
  0.25–0.401.18 (0.98 to 1.41)0.0751.26 (1.11 to 1.43)<0.001
  0.41–0.681.15 (0.96 to 1.38)0.1381.42 (1.25 to 1.60)<0.001
  0.69–6.461.4 0 (1.16 to 1.69)0.0011.58 (1.39 to 1.80)<0.001
Model 3
 Adjusted A1c SD (ref <0.62)
  0.62–0.971.02 (0.86 to 1.21)0.8121.17 (1.04 to 1.32)0.008
  0.98–1.561.03 (0.87 to 1.22)0.7311.23 (1.10 to 1.38)0.001
  1.57–17.401.29 (1.09 to 1.54)0.0041.48 (1.31 to 1.67)<0.001
  • *The risk of HRH in 1-year and 3-year follow-up periods was assessed separately using the logistic regression model indicated in the Methods section.

  • †Each model was run with a measure of A1c variability in quartiles, A1c mean, and the covariates listed in the Methods section.

  • HRH, hypoglycemia-related hospitalization; ref, reference.