Table 2

Summary of A1c variability measures and HRH risk during 2-year follow-up period (n=342 058)*

Model†OR (95% CI)P value
Model 1
 A1c coefficient of variation (%) (ref <4)
  4–5.91.19 (1.04 to 1.36)0.011
  6–9.41.28 (1.13 to 1.47)<0.001
  9.5–661.44 (1.26 to 1.65)<0.001
 A1c mean (%) (ref=7–7.9)
  <60.66 (0.56 to 0.78)<0.001
  6–6.90.78 (0.71 to 0.86)<0.001
  8–8.91.11 (1.00 to 1.24)0.060
  ≥91.53 (1.33 to 1.75)<0.001
Model 2
 A1c SD (ref <0.25)
  0.25–0.401.26 (1.10 to 1.45)0.001
  0.41–0.681.36 (1.18 to 1.56)<0.001
  0.69–6.461.56 (1.35 to 1.81)<0.001
 A1c mean (%) (ref=7–7.9)
  <60.71 (0.59 to 0.84)<0.001
  6–6.90.81 (0.73 to 0.89)<0.001
  8–8.91.09 (0.98 to 1.22)0.125
  ≥91.49 (1.30 to 1.72)<0.001
Model 3
 Adjusted A1c SD (ref <0.62)
  0.62–0.971.08 (0.95 to 1.24)0.239
  0.98–1.561.12 (0.98 to 1.27)0.103
  1.57–17.401.37 (1.20 to 1.57)<0.001
 A1c mean (%) (ref=7–7.9)
  <60.67 (0.56 to 0.79)<0.001
  6–6.90.79 (0.71 to 0.87)<0.001
  8–8.91.09 (0.98 to 1.22)0.115
  ≥91.48 (1.29 to 1.70)<0.001

  • *One patient was dropped from logistic regression due to missing service-connected disability.

  • †Each model was run with a measure of A1c variability in quartiles, A1c mean, and the covariates listed in the Methods section.

  • HRH, hypoglycemia-related hospitalization; ref, reference.