Association of expression of the circulating lncRNA MALAT1 with different parameters among patients with T2DM
| Variable | Fold change in MALAT1 expression among patients with T2DM (mean±SD) | P value |
| Overall expression | 4.46±2.09 | – |
| Age (years) | ||
| ≤40 years | 4.28±2.26 | 0.38 |
| >40 years | 4.56±1.94 | |
| Sex | ||
| Male | 4.38±2.22 | 0.58 |
| Female | 4.56±1.94 | |
| Hypertension | ||
| Yes | 4.44±1.99 | 0.52 |
| No | 4.50±2.25 | |
| Nephropathy | ||
| Yes | 4.42±2.21 | 0.65 |
| No | 4.50±1.99 | |
| Weight loss | ||
| Yes | 4.85±2.05 | 0.003 |
| No | 4.02±2.06 | |
| Fatigue | ||
| Yes | 4.37±2.38 | 0.33 |
| No | 4.55±1.81 | |
| Slow wound healing | ||
| Yes | 4.31±1.97 | 0.35 |
| No | 4.67±2.26 | |
| Retinopathy | ||
| Yes | 5.02±2.30 | 0.01 |
| No | 4.18±1.93 | |
| Loss of appetite | ||
| Yes | 4.37±1.95 | 0.92 |
| No | 4.54±2.21 | |
| Smoking | ||
| Yes | 5.09±2.04 | <0.0001 |
| No | 3.92±1.99 | |
| Alcoholism | ||
| Yes | 5.20±2.05 | <0.0001 |
| No | 3.69±1.86 | |
lncRNA, long non-coding RNA; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; T2DM, type 2 diabetes mellitus.