Cumulative incidence of major adverse events
| | Group A (N=3395) | Group B (N=1755) | P value |
| n (%) | n (%) | Group A vs B | |
| Symptomatic hypoglycemia | 104 (3.9) | 45 (3.2) | 0.317 |
| Pancreatitis acute | 5 (0.2) | 3 (0.9) | 0.861 |
| Pancreatitis chronic | 2 (0.1) | 0 (0.0) | 0.310 |
| Skin disorders of non-extrinsic origin | 201 (7.9) | 90 (6.2) | 0.240 |
| Severe infections | 71 (2.7) | 28 (2.0) | 0.222 |
| Cancer | 162 (7.4) | 62 (4.8) | 0.040* |
Cumulative incidence (%) of major AEs was calculated per observation period by the Kaplan-Meier method (see figure 2). P values were by log-rank test. Potential factors contributing to cancer development were detailed by Cox regression analysis as shown in online supplemental table 3.
*p value with significance level smaller than 0.05.