Table 3

Cumulative incidence of major adverse events


Group A (N=3395)Group B (N=1755)P value
n (%)n (%)Group A vs B
Symptomatic hypoglycemia104 (3.9)45 (3.2)0.317
Pancreatitis acute5 (0.2)3 (0.9)0.861
Pancreatitis chronic2 (0.1)0 (0.0)0.310
Skin disorders of non-extrinsic origin201 (7.9)90 (6.2)0.240
Severe infections71 (2.7)28 (2.0)0.222
Cancer162 (7.4)62 (4.8)0.040*
  • Cumulative incidence (%) of major AEs was calculated per observation period by the Kaplan-Meier method (see figure 2). P values were by log-rank test. Potential factors contributing to cancer development were detailed by Cox regression analysis as shown in online supplemental table 3.

  • *p value with significance level smaller than 0.05.