Table 3

HRs (95% CI) of type 2 diabetes according to quintiles of IGF-1 levels stratified by GRS of birth weight

GRS for birth weightIGF-1 levels, in quintileP for trendPer SD
Q1Q2Q3Q4Q5
Q1
 Cases/person-years235/69,351137/71,584156/72,986125/73,66398/74,720751/362,304
 HR (95% CI)*1.000.83 (0.64 to 1.06)0.95 (0.75 to 1.22)0.87 (0.66 to 1.14)0.82 (0.61 to 1.09)0.250.96 (0.88 to 1.05)
Q2–Q5
 Cases/person-years829/283,910564/285,687443/284,652357/284,808355/283,4202548/1,422,477
 HR (95% CI)*1.000.86 (0.76 to 0.98)0.82 (0.71 to 0.93)0.68 (0.59 to 0.79)0.81 (0.70 to 0.95)<0.0010.92 (0.88 to 0.97)
P value for interaction0.47
  • *Adjusted for age, sex, overall health rating, Townsend Deprivation Index, smoking status, alcohol consumption, sleep duration, physical activity, birth weight, maternal smoking, family history of diabetes and history of hypertension, Body Mass Index, concentrations of C reactive protein, total cholesterol, triglycerides, high-density lipoprotein cholesterol, genetic batch and first 10 components of ancestry.

  • GRS, Genetic Risk Score; IGF-1, insulin-like growth factor-1.