Table 1

Baseline characteristics according to quintiles of IGF-1 levels in the UK Biobank

CharacteristicsIGF-1 levels, in quintile
Birth weight<2.5 kgBirth weight≥2.5 kg
Q1Q5Q1Q5
Age (years)58.6±7.152.9±8.257.9±7.251.6±7.9
Townsend Deprivation Index−1.1±3.2−1.5±2.9−1.4±3.0−1.7±2.8
Physical activity (MET-hours/week)44.5±39.444.1±39.044.3±40.843.1±39.2
BMI (kg/m2)28.5±5.926.4±4.128.0±5.626.4±3.9
Overall health rating
 Excellent503 (13.4)599 (17.5)5182 (16.0)7063 (21.6)
 Good2112 (56.4)2057 (60.0)19 154 (59.2)19 936 (61.0)
 Fair896 (23.9)640 (18.7)6658 (20.6)4914 (15.0)
 Poor234 (6.3)130 (3.8)1337 (4.1)775 (2.4)
Smoking
 Never2184 (58.4)2227 (64.9)17 161 (53.0)19 885 (60.8)
 Past1164 (31.1)888 (25.9)11 829 (36.6)9856 (30.1)
 Current392 (10.5)317 (9.2)3368 (10.4)2965 (9.1)
Alcohol intake
 Never380 (10.1)231 (6.7)2589 (8.0)1664 (5.1)
 Monthly to weekly2746 (73.1)2747 (79.8)22 280 (68.7)25 801 (78.8)
 Daily631 (16.8)464 (13.5)7563 (23.3)5297 (16.2)
Sleep duration (hours/day)
 7–82367 (63.5)2368 (69.1)21 503 (66.6)23 655 (72.4)
 ≤61006 (27.0)815 (23.8)8245 (25.5)7124 (21.8)
 ≥9357 (9.6)245 (7.2)2539 (7.9)1909 (5.8)
Family history of diabetes714 (21.9)683 (22.2)6006 (20.7)6327 (21.2)
History of hypertension1239 (32.9)816 (23.7)8507 (26.2)5852 (17.9)
Maternal smoking1280 (38.9)1109 (36.5)8605 (30.0)7915 (26.9)
TC (mmol/L)5.9±1.15.8±1.15.9±1.15.7±1.0
TG (mmol/L)1.8±1.01.7±1.01.7±1.01.6±0.9
HDL-C (mmol/L)1.5±0.41.5±0.41.5±0.41.5±0.3
CRP (mg/L)4.1±5.72.0±3.93.5±5.01.8±3.6
GRS for birth weight7.5±1.87.4±1.87.6±1.87.5±1.8
  • Data are presented as mean±SD or n (%).

  • BMI, Body Mass Index; CRP, C reactive protein; GRS, Genetic Risk Score; HDL-C, high-density lipoprotein cholesterol; IGF-1, insulin-like growth factor-1; MET, metabolic equivalent of task; TC, total cholesterol; TG, triglyceride.