Table 2

HRs (95% CI) of type 2 diabetes according to quintiles of IGF-1 levels

IGF-1 levels, in quintileP value for trendPer SD
Q1Q2Q3Q4Q5
All participants
Cases/person-years1064/353,261701/357,271599/357,639482/358,471453/358,1403299/1,784,781
 Model 11.000.71 (0.63 to 0.79)0.66 (0.59 to 0.75)0.53 (0.46 to 0.60)0.55 (0.48 to 0.63)<0.0010.80 (0.76 to 0.83)
 Model 21.000.82 (0.73 to 0.92)0.80 (0.71 to 0.90)0.67 (0.59 to 0.76)0.75 (0.66 to 0.86)<0.0010.90 (0.86 to 0.94)
 Model 31.000.85 (0.76 to 0.95)0.84 (0.74 to 0.94)0.72 (0.63 to 0.82)0.80 (0.70 to 0.92)<0.0010.93 (0.89 to 0.97)
  • Model 1: adjusted for age, sex (only in analyses of the all participants), overall health rating, Townsend Deprivation Index, smoking status, alcohol consumption, sleep duration, physical activity, birth weight, maternal smoking, family history of diabetes and history of hypertension.

  • Model 2: additionally adjusted for Body Mass Index.

  • Model 3: additionally adjusted for concentrations of C reactive protein, total cholesterol, triglycerides and high-density lipoprotein cholesterol.

  • IGF-1, insulin-like growth factor-1.