Multivariate regression for lowest phosphate during the first 24 hours of treatment in DKA
| Univariate standardized beta coefficient | P value | Multivariate standardized beta coefficient | P value | Part correlation | |
| Age (years) | 0.042 | 0.706 | |||
| Female gender (%) | −0.055 | 0.622 | |||
| BMI (kg/m2) | −0.118 | 0.290 | |||
| Current smoker (yes=1) | 0.118 | 0.289 | |||
| Smoking (pack-years) | −0.176 | 0.279 | |||
| Drugs (yes=1) | 0.018 | 0.878 | |||
| Use of alcohol (U/week) | 0.061 | 0.676 | |||
| Hypertension | −0.230 | 0.038 | −0.066 | 0.551 | |
| Temperature (°C) | 0.006 | 0.964 | |||
| EMV score | 0.092 | 0.449 | |||
| Diabetes duration (years) | 0.084 | 0.477 | |||
| Earlier DKA (yes=1) | 0.251 | 0.031 | |||
| Use of pen (yes=1) | 0.006 | 0.959 | |||
| Use of pump (yes=1) | −0.006 | 0.959 | |||
| Use of sensor (yes=1) | −0.203 | 0.081 | |||
| Insulin dose (U/day) | 0.159 | 0.322 | |||
| HbA1c (%) | −0.040 | 0.773 | |||
| HbA1c (mmol/mol) | −0.008 | 0.956 | |||
| Microvascular complications (yes=1) | 0.052 | 0.659 | |||
| Retinopathy (yes=1) | −0.034 | 0.771 | |||
| Neuropathy (yes=1) | 0.122 | 0.298 | |||
| Nephropathy (yes=1) | 0.059 | 0.613 | |||
| Macrovascular complications (yes=1) | 0.041 | 0.727 | |||
| Cause DKA | |||||
| New-onset T1DM (yes=1) | −0.341 | 0.002 | −0.089 | 0.437 | |
| Therapy non-adherence (yes=1) | 0.181 | 0.129 | |||
| Infection/Inflammation (yes=1) | −0.053 | 0.660 | |||
| Laboratory measurements | |||||
| Hb (mmol/L) | −0.397 | 0.000 | −0.330 | 0.002 | −0.367 |
| White blood cell count (109/L) | −0.156 | 0.166 | |||
| Platelet count (109/L) | −0.132 | 0.241 | |||
| CRP (mg/L) | −0.091 | 0.427 | |||
| Serum creatinine (μmol/L) | 0.269 | 0.016 | 0.100 | 0.414 | |
| eGFR (mL/min/1.73 m2) | −0.327 | 0.055 | |||
| Serum sodium (mmol/L) | −0.223 | 0.046 | −0.136 | 0.202 | |
| Serum potassium (mmol/L) | 0.247 | 0.027 | 0.059 | 0.680 | |
| Serum glucose (mmol/L) | 0.112 | 0.330 | |||
| Serum phosphate (mmol/L) | 0.251 | 0.123 | |||
| Serum urea (mmol/L) | 0.254 | 0.026 | 0.219 | 0.508 | |
| pH (kPa) | 0.229 | 0.057 | |||
| Serum bicarbonate (mmol/L) | 0.390 | 0.001 | 0.431 | 0.000 | 0.457 |
| Arterial pCO2 (kPa) | 0.392 | 0.000 | |||
| Arterial saturation (%) | −0.243 | 0.104 | |||
| Lactate (mmol/L) | 0.056 | 0.651 | |||
pH and arterial pCO2 were excluded because of collinearity with bicarbonate levels. Significant (p<0.05) outcomes are presented in bold.
BMI, body mass index; CRP, C reactive protein; DKA, diabetic ketoacidosis; eGFR, estimated glomerular filtration rate; EMV, Eye opening, best Motor response, best Verbal response; HbA1c, glycosylated hemoglobin; T1DM, type 1 diabetes mellitus.