The OR of GLP-1 analog response and the methylation status of VTRNA2-1 among the patients with type 2 diabetes mellitus in the different genotypes of rs2346018
| GLP-1 analog | OR | 95% CI | P value | ||
| Responsive | Non-responsive | ||||
| VTRNA2-1 (with all genotypes of rs2346018) | |||||
| Hypermethylation (≧40%) | 65 | 16 | |||
| Hypomethylation (<40%) | 28 | 19 | 2.757 | 1.240 to 6.130 | 0.011* |
| VTRNA2-1 (with CC genotypes) | |||||
| Hypermethylation (≧40%) | 31 | 7 | |||
| Hypomethylation (<40%) | 14 | 4 | 1.265 | 0.318 to 5.035 | 0.738 |
| VTRNA2-1 (with CA or AA genotypes) | |||||
| Hypermethylation (≧40%) | 34 | 9 | |||
| Hypomethylation (<40%) | 14 | 15 | 4.048 | 1.438 to 11.389 | 0.007** |
| rs2346018 genotypes | |||||
| CC | 45 | 11 | |||
| CA or AA | 48 | 24 | 0.460 | 0.203 to 1.042 | 0.075 |
| CC or CA | 87 | 29 | |||
| AA | 6 | 6 | 0.349 | 0.104 to 1.165 | 0.095 |
The p values were determined using the χ² test, *p<0.05, **p<0.01.
GLP-1, glucagon-like peptide-1.