Table 1

The OR of GLP-1 analog response and the methylation status of VTRNA2-1 among the patients with type 2 diabetes mellitus in the different genotypes of rs2346018

GLP-1 analogOR95% CIP value
VTRNA2-1 (with all genotypes of rs2346018)
Hypermethylation (≧40%)6516
Hypomethylation (<40%)28192.7571.240 to 6.1300.011*
VTRNA2-1 (with CC genotypes)
Hypermethylation (≧40%)317
Hypomethylation (<40%)1441.2650.318 to 5.0350.738
VTRNA2-1 (with CA or AA genotypes)
Hypermethylation (≧40%)349
Hypomethylation (<40%)14154.0481.438 to 11.3890.007**
rs2346018 genotypes
CA or AA48240.4600.203 to 1.0420.075
CC or CA8729
AA660.3490.104 to 1.1650.095
  • The p values were determined using the χ² test, *p<0.05, **p<0.01.

  • GLP-1, glucagon-like peptide-1.