Table 2

Selected individual metabolites and their associations with GDM risk by study visit

MetaboliteRT_m/zCorresponding lipid networkVisit 0 (10–14 weeks)Visit 1 (15–26 weeks)
Network membership score*EstimateFDRNetwork membership score*EstimateFDR
TG (50:1)10.80_850.79Brown0.800.540.00030.800.510.0006
TG (50:2)10.41_853.73Brown0.550.550.00030.640.430.0037
TG (50:2)10.41_848.77Brown0.730.540.00030.730.430.0037
TG (54:5)10.32_903.740.500.00110.440.0043
CE (18:2)10.37_671.57Turquoise0.95−0.520.00110.94−0.330.0290
Unannotated10.80_551.500.500.00110.510.0006
TG (48:1)10.38_822.75Brown0.930.480.00160.920.420.0049
Unannotated10.39_549.490.470.00160.370.0097
TG (48:1)10.38_827.71Brown0.930.480.00170.940.360.0170
TG (50:1)10.80_855.74Brown0.510.470.00290.530.410.0059
DG (34:1)6.85_612.56Yellow0.830.440.00480.750.450.0031
TG (52:1)11.20_878.82Yellow0.810.430.00540.800.500.0011
PC (38:3)5.79_812.610.420.00540.360.0200
Unannotated10.80_577.520.420.00540.440.0021
TG (48:2)9.98_820.74Brown0.840.430.00540.880.340.0230
TG (50:3)10.01_846.76Yellow0.800.420.00540.760.410.0046
TG (52:1)11.20_883.77Brown0.570.420.00590.630.480.0016
TG (58:6)10.65_957.790.440.00590.430.0047
DG (34:1)6.85_617.51Yellow0.670.420.00590.460.430.0037
Unannotated11.20_899.750.400.00640.400.0047
TG (48:0)10.81_824.77Brown0.780.410.00720.820.520.0008
TG (58:6)10.65_952.83Yellow0.680.410.01170.710.440.0037
CE (18:1)10.85_673.59Turquoise0.89−0.400.01330.88−0.530.0004
TG (46:0)10.36_796.74Brown0.930.370.01650.960.410.0073
Unannotated6.39_615.490.360.01970.470.0016
Unannotated10.31_951.810.370.02040.390.0071
TG (51:1)10.93_869.76Yellow0.800.370.02210.760.360.0120
TG (51:1)10.93_864.80Yellow0.900.360.02210.840.360.0120
CE (18:1)10.85_668.63Turquoise0.94−0.360.02670.92−0.400.0047
TG (54:2)11.20_904.83Yellow0.790.360.02810.820.430.0047
TG (54:1)11.56_906.85Yellow0.770.350.03280.860.450.0042
CE (22:6)9.88_719.57Turquoise0.94−0.340.03280.94−0.340.0250
TG (56:4)10.88_933.790.330.03880.400.0049
TG (49:1)10.59_836.77Yellow0.800.320.04150.740.280.0470
Unannotated10.17_896.790.320.04150.330.0270
TG (48:0)10.81_829.73Brown0.670.320.04840.730.410.0071
  • FDR q values were calculated based on 420 individual tests for 420 metabolites.

  • *Network membership score represents a measure of importance for member metabolites within a network and ranges between −1 and 1. Network membership scores were not presented for metabolites that failed to form a network and for unannotated metabolites.

  • CE, cholesteryl esters; DG, diglyceride; FDR, false discovery rate; GDM, gestational diabetes; GlcCer, glucosylceramide; LPC, lysophosphatidylcholine; PC, phosphatidylcholine; RT_m/z, retention time_mass-to-charge ratio; SM, sphingomyelin; TG, triglyceride.