Table 2

Metabolic measurements in BA and WE men

BA (n=23)WE (n=23)Mean difference or ratio of geometric mean (95% CI)P value
Fasting glucose (mmol/L)5.05 (0.35)5.15 (0.34)0.10 (−0.11 to 0.30)0.36
iAUC glucose (mmol/L×180 min)‡92.7 (68.4, 125.6)96.8 (63.1, 148.4)1.04 (0.63 to 1.74)0.86
Fasting insulin (pmol/L)‡51.7 (41.4, 64.6)54.5 (42.3, 70.1)1.05 (0.76 to 1.46)0.75
iAUC insulin (pmol/L×180 min)‡47.6 (39.1, 58.0) ×10340.9 (31.2, 53.4) ×1030.86 (0.62 to 1.18)0.33
Fasting C peptide (nmol/L)‡1.53 (1.27, 1.84)1.82 (1.48, 2.23)1.19 (0.91 to 1.56)0.21
AUCC peptide (nmol/L×180 min)207.7 (81.3)271.2 (175)63.5 (−17.7 to 144.7)0.13
AUCISR (pmol/m2 BSA×180 min)‡41.1 (35.5, 47.6) ×10346.5 (36.7, 58.9) ×1031.13 (0.86 to 1.48)0.37
Mean IPL (%)*†‡6.33 (5.24, 7.65)6.24 (5.11, 7.62)0.99 (0.75 to 1.29)0.92
M/I* (mg/kg FFM/min)/(pmol/L)0.0171 (0.0059)0.0189 (0.0094)0.00184 (−0.0030 to 0.0066)0.44
Insulin clearance (mL/m2 BSA/min)697 (171)819 (173)122 (18.3 to 225)0.006
Visceral adipose tissue (cm2)†48.2 (35.5, 64.6)79.0 (55.0, 112.2)1.64 (1.05 to 2.56)0.035
Fasting NEFAs (mmol/L)‡0.38 (0.29, 0.51)0.42 (0.33, 0.54)1.09 (0.75 to 1.59)0.63
AUC NEFAs (mmol/L×180 min)37.5 (31.2, 45.1)31.0 (25.3, 37.8)0.82 (0.63 to 1.07)0.15
Fasting GLP-1 (pmol/L)16.2 (9.0)16.8 (8.5)0.61 (−4.6 to 5.9)0.82
Fasting GIP (ng/L)164.6 (71.0)202.5 (69.7)37.9 (−4.4 to 80.2)0.08
iAUC GLP-1 (pmol/L×180 min)‡1186.6 (849.2, 1658.1)1580.9 (1232.3, 2028.6)1.09 (0.75 to 1.59)0.16
iAUC GIP (ng/L×180 min)‡44 937 (32 501, 62 116)36 149 (25 509, 51 239)0.80 (0.51 to 1.28)0.35
Fasting glucagon (ng/L)‡66.2 (52.5, 83.4)70.2 (57.3, 86.1)1.06 (0.79 to 1.43)0.69
iAUC glucagon (ng/L×30 min)‡564.3 (319.3, 997.2)813.8 (615.2, 1076)1.44 (0.78 to 2.68)0.23
iAUC glucagon (ng/L×180 min)‡4535 (3003, 6849)5111 (3546, 7367)1.13 (0.66 to 1.91)0.65
  • Data presented as mean (SD) and mean difference, or geometric mean (95% CI) and ratio of the geometric mean for log-transformed data.

  • Differences between the two ethnic groups were determined using independent samples t-tests.

  • *Previously reported data.27 28

  • †BA n=20, WE n=23.

  • ‡Log-transformed.

  • AUC, area under the curve; AUCISR, total endogenous beta cell insulin secretory response; BA, black African; BSA, body surface area; FFM, fat-free mass; GIP, gastric inhibitory polypeptide; GLP-1, glucagon-like peptide 1; iAUC, incremental area under the curve; IPL, intrapancreatic lipid; M/I, insulin sensitivity corrected for insulin concentrations; NEFAs, non-esterified fatty acids; WE, white European.