Table 1

Comparison of clinical characteristics and FGF21 among three DR levels

CharacteristicsNDRNSTDRSTDRP value
Case (male/female)345 (185/160)207 (107/100)102 (55/47)/
Age (year)57.11±11.9958.41±10.1358.93±10.710.190
Duration of diabetes (year)7.11±5.769.95±6.24*11.81±7.27*†0.000
BMI (kg/m2)25.28±3.6425.31±3.1425.11±3.740.679
SBP (mm Hg)128.19±14.22127.65±14.53128.79±15.210.544
DBP (mm Hg)78.84±7.8277.59±7.3178.61±7.970.678
Smoking (%)31.236.426.00.226
Drinking (%)17.419.215.40.423
Coronary artery disease (%)8.710.214.90.241
Cerebral infraction (%)6.29.68.10.277
FPG (mmol/L)7.79±2.618.49±3.258.07±2.660.118
PPG (mmol/L)12.53±4.3913.14±4.5712.32±4.610.393
HbA1c (%)7.73±1.888.28±1.77*8.49±1.93*0.000
GA (%)20.47±6.3222.18±5.74*22.79±6.49*0.000
BUN (mmol/L)5.24±1.295.31±1.156.03±2.02*†0.008
Cr (μmol/L)62.44±15.8165.56±15.28*71.55±20.84*†0.001
UA (μmol/L)315.58±82.92306.27±79.05332.24±84.470.071
TC (mmol/L)4.92±1.054.80±1.035.11±1.240.210
TG (mmol/L)1.79±1.461.99±1.511.81±1.500.140
HDL-C (mmol/L)1.12±0.271.08±0.251.15±0.320.100
LDL-C (mmol/L)2.95±0.862.83±0.793.02±0.770.177
FGF21 (pg/mL)326.8±81.6572.7±79.5*625.8±83.7*†0.000
  • *P<0.01 vs NDR.

  • †P<0.01 vs NSTDR.

  • BMI, body mass index; BUN, blood urea nitrogen; Cr, creatinine; DBP, diastolic blood pressure; FGF21, fibroblast growth factor 21; FPG, fasting plasma glucose; GA, glycosylated albumin; HbA1c, glycosylated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NDR, no diabetic retinopathy; NSTDR, non-sight threatening diabetic retinopathy; PPG, postprandial blood glucose; SBP, systolic blood pressure; STDR, sight-threatening diabetic retinopathy; TC, total cholesterol; TG, triglyceride; UA, uric acid.