Table 2

Comparison of heat shock and related proteins between control (n=23) and type 2 diabetes (n=23) subjects at baseline and comparison of heat shock and related proteins between diabetes at baseline and following establishment of normoglycemia (4.5±0.07 mmol/L: 81±1.2 mg/dL) for 1 hour by a hyperinsulinemic clamp

ProteinControl baseline mean±SD (RFU)Diabetes baseline mean±SD (RFU)P valueT2D baseline mean±SD (RFU)T2D normoglycemia mean±SD (RFU)P value
HSP90alpha-A1174±39.2165±38.00.22165±38.0168±39.40.38
HSP90alpha-B117308±304617951±31270.2417951±312718023±29750.47
HSP70-1A5686±11615300±11570.135300±11574983±12290.09
HSP70-81126±2361043±1920.821043±1921045±1410.18
HSPB11766±7031592±6040.191592±6041344±5520.07
HSPD13588±22603840±28050.373840±28053378±13990.24
CDC37280±31.4290±40.00.18290±40.0282±30.20.25
DNAJB1404±111396±93.30.39396±93.3343±77.00.02
PPID545±297660±3550.12660±355552±3110.14
STIP14656±12714467±9440.284467±9444518±8180.42
CHIP802±256519±93.40.03519±93.4522±1050.46
UBE2G23525±8284331±10490.0034331±10494365±13590.9
HSP 90a/b4598±10314967±8540.14967±8544740±8000.18
  • HSP, heat shock protein; HSPB1, heat shock protein beta-1; PPID, peptidyl-prolylcis-transisomerase D; RFU, relative fluorescent unit; STIP1, stress-induced-phosphoprotein-1; T2D, type 2 diabetes; UBE2G2, ubiquitin-conjugating enzyme E2G2.