Adjusted ORs and 95% CIs for any fracture or fall-related fracture according to severe hypoglycemia in patients with type 1 diabetes
| Any fracture | Fall-related fracture | |||
| Without severe hypoglycemia | With severe hypoglycemia | Without severe hypoglycemia | With severe hypoglycemia | |
| Number of patients with fracture | 22 | 42 | 17 | 31 |
| Number of total patients | 226 | 162 | 226 | 162 |
| Percentage of patients with fracture (%) | 9.7 | 25.9 | 7.5 | 19.1 |
| ORs (95% CI) | ||||
| Unadjusted | 1.0 (ref.) | 3.25 (1.87 to 5.78) | 1.0 (ref.) | 2.90 (1.57 to 5.57) |
| Age-adjusted and sex-adjusted | 1.0 (ref.) | 3.12 (1.78 to 5.62) | 1.0 (ref.) | 2.98 (1.59 to 5.79) |
| Multivariate adjusted | 1.0 (ref.) | 2.10 (1.11 to 4.06) | 1.0 (ref.) | 1.93 (0.94 to 4.04) |
| Multivariate adjusted+neuropathy, diabetic retinopathy, DKD | 1.0 (ref.) | 2.11 (1.11 to 4.09) | 1.0 (ref.) | 1.91 (0.93 to 4.02) |
Multivariate adjustments include age, sex, BMI, diabetes duration, current smoking habit, current drinking habit, exercise habit, family history of hip fracture, weight loss, and hemoglobin A1c.
BMI, body mass index; DKD, diabetic kidney disease.