Table 2

Adjusted ORs and 95% CIs for any fracture or fall-related fracture according to severe hypoglycemia in patients with type 1 diabetes

Any fractureFall-related fracture
Without severe hypoglycemiaWith severe hypoglycemiaWithout severe hypoglycemiaWith severe hypoglycemia
Number of patients with fracture22421731
Number of total patients226162226162
Percentage of patients with fracture (%)9.725.97.519.1
ORs (95% CI)
 Unadjusted1.0 (ref.)3.25 (1.87 to 5.78)1.0 (ref.)2.90 (1.57 to 5.57)
 Age-adjusted and sex-adjusted1.0 (ref.)3.12 (1.78 to 5.62)1.0 (ref.)2.98 (1.59 to 5.79)
 Multivariate adjusted1.0 (ref.)2.10 (1.11 to 4.06)1.0 (ref.)1.93 (0.94 to 4.04)
 Multivariate adjusted+neuropathy, diabetic retinopathy, DKD1.0 (ref.)2.11 (1.11 to 4.09)1.0 (ref.)1.91 (0.93 to 4.02)
  • Multivariate adjustments include age, sex, BMI, diabetes duration, current smoking habit, current drinking habit, exercise habit, family history of hip fracture, weight loss, and hemoglobin A1c.

  • BMI, body mass index; DKD, diabetic kidney disease.