Mortality | Graft failure | |
HR (95% CI) | HR (95% CI) | |
Recipient characteristics | ||
Primary cause of ESKD | ||
Non-diabetes | 1.0 (reference) | 1.0 (reference) |
T1D | 1.95 (1.88 to 2.03) | 1.24 (1.18 to 1.31) |
T2D | 1.65 (1.62 to 1.69) | 1.32 (1.28 to 1.36) |
Sex (female vs male) | 0.92 (0.90 to 0.94) | 0.98 (0.95 to 1.00) |
Age (years) | 1.05 (1.05 to 1.05) | 0.99 (0.98 to 0.99) |
Race | ||
Non-Hispanic white | 1.0 (reference) | 1.0 (reference) |
Non-Hispanic black | 0.80 (0.78 to 0.82) | 1.50 (1.45 to 1.54) |
Hispanic | 0.67 (0.65 to 0.69) | 0.97 (0.93 to 1.01) |
Other | 0.67 (0.64 to 0.69) | 0.85 (0.81 to 0.90) |
ESKD duration* (years) | 1.06 (1.05 to 1.06) | 1.04 (1.03 to 1.10) |
Health insurance status (%) | ||
Private | 1.0 (reference) | 1.0 (reference) |
Medicare | 1.20 (1.17 to 1.23) | 1.28 (1.25 to 1.32) |
Medicaid | 1.23 (1.16 to 1.29) | 1.28 (1.21 to 1.35) |
Other | 1.01 (0.94 to 1.10) | 0.94 (0.84 to 1.06) |
BMI (kg/m2)† | 1.00 (1.00 to 1.00) | 1.01 (1.01 to 1.01) |
History of smoking (yes vs no) | 1.11 (1.08 to 1.15) | 1.13 (1.09 to 1.18) |
Comorbidities | ||
CHF (yes vs no) | 1.39 (1.36 to 1.42) | 1.34 (1.30 to 1.38) |
Stroke (yes vs no) | 1.27 (1.22 to 1.32) | 1.10 (1.04 to 1.17) |
COPD (yes vs no) | 1.54 (1.48 to 1.60) | 1.28 (1.04 to 1.17) |
PVD (yes vs no) | 1.30 (1.26 to 1.35) | 1.13 (1.07 to 1.19) |
Cancer (yes vs no) | 1.20 (1.14 to 1.27) | 1.09 (1.00 to 1.18) |
Graft failure | 1.95 (1.91 to 1.98) | NA |
Donor characteristics | ||
Age (years)† | 1.00 (1.00 to 1.00) | 1.01 (1.01 to 1.01) |
Sex (male vs female) | 1.01 (0.99 to 1.03) | 1.07 (1.05 to 1.10) |
Race | ||
Non-Hispanic white | 1.0 (reference) | 1.0 (reference) |
Non-Hispanic black | 1.04 (1.01 to 1.07) | 1.22 (1.17 to 1.26) |
Hispanic | 0.94 (0.91 to 0.97) | 1.01 (0.97 to 1.05) |
Other | 0.98 (0.93 to 1.03) | 1.05 (0.99 to 1.13) |
Cold ischemic time (hours)† | 1.00 (1.00 to 1.00) | 1.01 (1.00 to 1.01) |
Donor risk level‡ | ||
LD | 1.0 (reference) | 1.0 (reference) |
Low DD risk | 1.15 (1.10 to 1.19) | 1.16 (1.10 to 1.22) |
Moderate DD risk | 1.20 (1.16 to 1.23) | 1.39 (1.33 to 1.44) |
High DD risk | 1.36 (1.31 to 1.42) | 2.14 (2.03 to 2.25) |
KDPI is estimated among DD only and is defined as low risk (KDPI=0–20), moderate risk (KDPI >20–85) or high risk (KDPI >85).
*ESKD duration prior to transplant date.
†Variables reported as HR: 1.00 (95% CI: 1.00 to 1.00) are significantly (and positively) associated with the outcome, but rounding has obscured associations.
‡High-risk donor is defined using KDPI.
BMI, body mass index; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; DD, deceased donor; ESKD, end-stage kidney disease; KDPI, Kidney Donor Percentage Index; LD, living donor; NA, not applicable; PVD, peripheral vascular disease; T1D, type 1 diabetes; T2D, type 2 diabetes.