Table 1

Gene sets found to be differentially expressed (FDR<0.25) in exocrine tissue between non-diabetic and type 1 diabetes subjects

Gene set	N of genes	P value	FDR
Upregulated gene sets Exo1
HALLMARK_ESTROGEN_RESPONSE_EARLY	171	0.000668	0.0277
HALLMARK_MYC_TARGETS_V2	58	0.00111	0.0277
HALLMARK_P53_PATHWAY	172	0.00174	0.0290
HALLMARK_ADIPOGENESIS	180	0.00238	0.0297
HALLMARK_TNFA_SIGNALING_VIA_NFKB	172	0.00471	0.0431
HALLMARK_WNT_BETA_CATENIN_SIGNALING	35	0.00517	0.0430
HALLMARK_MYC_TARGETS_V1	192	0.00794	0.0567
HALLMARK_UNFOLDED_PROTEIN_RESPONSE	106	0.0125	0.0694
HALLMARK_CHOLESTEROL_HOMEOSTASIS	68	0.0125	0.0694
HALLMARK_HYPOXIA	160	0.0156	0.0777
HALLMARK_HEME_METABOLISM	161	0.0171	0.0777
HALLMARK_UV_RESPONSE_UP	136	0.0230	0.0959
HALLMARK_XENOBIOTIC_METABOLISM	162	0.0361	0.139
HALLMARK_FATTY_ACID_METABOLISM	141	0.0509	0.182
HALLMARK_PROTEIN_SECRETION	95	0.0672	0.210
Downregulated gene sets Exo1
HALLMARK_ALLOGRAFT_REJECTION	149	0.0671	0.210
Upregulated gene sets Exo2
HALLMARK_MYC_TARGETS_V2	58	0.00347	0.174
Downregulated gene sets Exo2
–	–	–	–
Upregulated gene sets Exo3
HALLMARK_MYC_TARGETS_V2	58	0.000386	0.0181
HALLMARK_ESTROGEN_RESPONSE_EARLY	171	0.000722	0.0181
HALLMARK_UNFOLDED_PROTEIN_RESPONSE	106	0.00239	0.0398
HALLMARK_ADIPOGENESIS	180	0.00408	0.0409
HALLMARK_MYC_TARGETS_V1	192	0.00409	0.0409
HALLMARK_TNFA_SIGNALING_VIA_NFKB	172	0.00535	0.0446
HALLMARK_HEME_METABOLISM	161	0.0112	0.0705
HALLMARK_WNT_BETA_CATENIN_SIGNALING	35	0.0137	0.0705
HALLMARK_HYPOXIA	160	0.0138	0.0705
HALLMARK_FATTY_ACID_METABOLISM	141	0.0165	0.0705
HALLMARK_PROTEIN_SECRETION	95	0.0167	0.0705
HALLMARK_XENOBIOTIC_METABOLISM	162	0.0169	0.0705
HALLMARK_P53_PATHWAY	172	0.0202	0.0779
HALLMARK_UV_RESPONSE_UP	136	0.0253	0.0903
HALLMARK_OXIDATIVE_PHOSPHORYLATION	177	0.0472	0.1574
HALLMARK_GLYCOLYSIS	169	0.0526	0.164
Downregulated gene sets Exo3
–	–	–	–

FDR, false discovery rate.