2-hour glucose (n=354) | Fasting glucose (n=388) | HbA1c (n=388) | |||||

IRR (95% CI) | P value | IRR (95% CI) | P value | IRR (95% CI) | P value | ||

WMH volume | A | 1.01 (1.01 to 1.02) | <0.001 | 1.00 (0.99 to 1.01) | 0.710 | 2.01 (1.37 to 2.93) | <0.001 |

B | 1.01 (1.00 to 1.01) | <0.001 | 1.00 (1.00 to 1.01) | 0.455 | 1.38 (1.05 to 1.81) | 0.021 | |

C | 1.01 (1.00 to 1.01) | <0.001 | 1.00 (1.00 to 1.01) | 0.389 | 1.23 (1 to 1.51) | 0.050 |

IRRs are from zero-inflated negative binomial regression models.

A, unadjusted; B, adjusted for age and gender; C, adjusted for age, gender, hypertension, low-density lipoprotein cholesterrol, Body Mass Index, smoking, and alcohol consumption; HbA1c, glycated hemoglobin; IRR, incidence rate ratio; WMH, white matter hyperintensity.