Association of diabetes status with WMH volume
| Participants with pre-diabetes versus normoglycemic control participants | Participants with diabetes versus normoglycemic control participants | Participants with pre-diabetes versus participants with diabetes | |||||
| IRR (95% CI) | P value | IRR (95% CI) | P value | IRR (95% CI) | P value | ||
| WMH volume | A | 2.17 (1.48 to 3.17) | <0.001 | 2.69 (1.70 to 4.25) | <0.001 | 0.81 (0.48 to 1.34) | 0.406 |
| B | 1.84 (1.26 to 2.70) | 0.002 | 1.96 (1.22 to 3.16) | 0.005 | 0.94 (0.58 to 1.51) | 0.793 | |
| C | 1.87 (1.28 to 2.75) | 0.001 | 1.75 (1.07 to 2.87) | 0.026 | 1.07 (0.66 to 1.72) | 0.788 | |
IRRs are from zero-inflated negative binomial regression models.
A, unadjusted; B, adjusted for age; C, adjusted for age, gender, hypertension, low-density lipoprotein cholesterol, Body Mass Index, smoking, and alcohol consumption; IRR, incidence rate ratio; WMH, white matter hyperintensity.