Table 2

Parameters at start and after 60 min of euglycemic and hypoglycemic clamps: before administering respective drugs during protocol 2

Euglycemic clamp (first 60 min)Hypoglycemic clamp (first 60 min)
Propionic acidPlaceboPropionic acidPlacebo
PreclampClamp at 60 minPreclampClamp at 60 minPreclampClamp at 60 minPreclampClamp at 60 min
Glucose (mg/dL)82.9 (1.6)90.1 (1.6)**85.9 (1.6)89.1 (1.6)84.5 (1.4)69.3 (1.4)***83.3 (1.4)71.3 (1.4)***
Insulin (μIU/mL)6.3 (2.6)42.2 (2.6)***8.1 (2.6)43.1 (2.6)***4.9 (1.4)40.5 (1.4)***4.7 (1.4)38.7 (1.4)***
Glucagon (pg/mL)61 (3)41 (3)**61 (3)48 (3)**72 (5)70 (5)66 (5)67 (5)
Norepinephrine (pg/mL)288 (28)282 (28)287 (28)320 (28)238 (19)262 (19)223 (19)277 (19)*
Epinephrine (pg/mL)32 (3)27 (3)31 (3)28 (3)30 (6)44 (6)34 (6)52 (6)*
EGP (µmol/kg/min)10.31 (0.31)7.40 (0.31)***10.72 (0.31)7.52 (0.31)***10.70 (0.34)7.89 (0.34)***10.73 (0.34)7.95 (0.34)***
  • *p<0.05; **p<0.01, ***p<0.0001 comparing T=240 min (preclamp) with T=300 min (clamp at 60 min).

  • EGP, endogenous glucose production.