Multistate model transition matrix according to patients’ risk
| Transition ‘states’ | HR (95% CI)* | P value |
| Transition 1: from baseline to WKF | 1.37 (1.21 to 1.56) | <0.001 |
| Transition 2: from baseline to CVD/HHF | 4.76 (3.63 to 6.23) | <0.001 |
| Transition 2: from WKF to CVD/HHF | 6.20 (2.71 to 14.8) | <0.001 |
WKF defined as >40% estimated glomerular filtration rate drop from baseline.
*HR comparing a medium-risk/high-risk patient with a low-risk patient. A low-risk patient is a patient with up to 3 risk points. A patient with more than 3 risk points is a medium-risk/high-risk patient (see also online supplemental table 1).
CVD, cardiovascular death; HHF, hospitalization for heart failure; WKF, worsening kidney function.