Table 2

Deterministic results from the application of the model per average person modeled

ParameterTreatmentPlaceboIncremental
Younger population results
Outcomes
Overall survival, years25.8623.302.56
Percent alive at time horizon0.00.00.0
Discounted QALYs16.1114.561.55
Cumulative events within time horizon
 Coronary heart disease47.1%61.1%–14.0%
 Stroke56.0%68.4%–12.5%
 Retinopathy55.0%59.2%–4.2%
 Overt nephropathy9.6%12.8%–3.2%
 ESRD8.0%11.3%–3.4%
 Hemodialysis6.1%9.0%–2.8%
 Amputation3.2%6.8%–3.5%
Discounted costs, ¥
Diabetes drug costs
 Treatment3 571 26503 571 265
 Diabetes management (no complications)1 494 3151 374 302120 013
Complications
 Coronary heart disease883 1121 213 304–330 191
 Stroke1 059 9571 397 376–337 419
 Retinopathy411 363445 265–33 902
 Overt nephropathy19 25425 221–5966
 ESRD15 36019 483–4123
 Hemodialysis651 037786 699–135 661
 Amputation18 19439 060–20 866
Total costs, ¥8 123 8575 300 7082 823 149
ICER¥1 825 163 per QALY
Older population results
Outcomes
Overall survival, years7.496.750.74
Percent alive at time horizon0.00.00.0
Discounted QALYs5.504.880.62
Cumulative events within time horizon
 Coronary heart disease28.0%40.3%–12.2%
 Stroke53.1%68.0%–14.8%
 Retinopathy19.1%21.8%–2.7%
 Overt nephropathy89.8%95.6%–5.8%
 ESRD64.7%73.7%–9.0%
 Hemodialysis34.9%42.2%–7.3%
 Amputation0.9%2.0%–1.2%
Discounted costs, ¥
Diabetes drug costs
 Treatment1 240 98701 240 987
 Diabetes management (no complications)519 263471 67347 590
Complications
 Coronary heart disease355 302511 481–156 179
 Stroke981 0551 321 155–340 100
 Retinopathy85 79896 838–11 040
 Overt nephropathy169 670189 681–20 012
 ESRD72 51077 280–4771
 Hemodialysis1 214 6151 194 56320 053
 Amputation37718473–4703
Total costs, ¥4 642 9713 871 145771 826
ICER¥1 247 591 per QALY
  • ESRD, end-stage renal disease; ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life year.