Summary of multivariable regression results of the association of body mass index (BMI) subgroup with different clinical responses in Asian participants with type 2 diabetes
| BMI <25 vs ≥30 kg/m2 | BMI 25–<30 vs ≥30 kg/m2 | |||
| Estimated difference (95% CI) | P value | Estimated difference (95% CI) | P value | |
| Change in HbA1c, % | 0.18 (–0.09 to 0.44) | 0.187 | –0.02 (–0.27 to 0.22) | 0.857 |
| Change in FPG, mmol/L | –0.26 (–0.83 to 0.30) | 0.360 | –0.23 (–0.76 to 0.31) | 0.402 |
| Change in 2-hour PPG, mmol/L | 0.47 (–0.74 to 1.67) | 0.448 | 0.10 (–1.04 to 1.24) | 0.861 |
| Change in body weight, kg | 0.68 (0.09 to 1.26) | 0.023 | 0.13 (–0.42 to 0.67) | 0.654 |
| Change in basal insulin dose, U/day | 0.48 (–1.20 to 2.15) | 0.576 | 0.14 (–1.43 to 1.71) | 0.858 |
| Endpoint basal insulin dose, U/day | –13.95 (–16.14 to 11.76) | <0.001 | –9.41 (–11.46 to 7.35) | <0.001 |
| Change in basal insulin dose, U/kg/day | 0.007 (–0.018 to 0.032) | 0.593 | 0.005 (–0.018 to 0.029) | 0.645 |
| Endpoint basal insulin dose, U/kg/day | 0.007 (–0.018 to 0.032) | 0.593 | 0.005 (–0.018 to 0.029) | 0.645 |
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Endpoint HbA1c <7% | 0.97 (0.48 to 1.93) | 0.691 | 1.15 (0.60 to 2.21) | 0.519 |
| Endpoint HbA1c <7% and no body weight gain | 0.40 (0.18 to 0.90) | 0.005 | 1.02 (0.50 to 2.07) | 0.089 |
FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; PPG, postprandial glucose.