Table 1

Characteristics of study population and statistical analyses for the complete 2019 database (n=94) and follow-up screening grade comparisons (n=71)

Variable (n=94)		Value	vs worst-eye retinopathy (P)	vs worst-eye maculopathy (P)
Mean age (range)		56.97 (29–87)	0.40	0.51
Gender, n (%)	Female	18 (19.1)	0.64	0.42
Gender, n (%)	Male	76 (80.9)	0.64	0.42
Mean duration of chronic pancreatitis, years (IQR)		13.56 (8)	0.001	<0.001
Mean duration of diabetes, years (IQR)		10.29 (7)	0.001	0.030
Mean most recent HbA1c %/mmol/mol (SD)		8.9/74.33 (4.1/20.90)	0.94	0.30
Mean BMI, kg/m² (SD)		25.30 (5.99)	0.55	0.22
Mean weight, kg (range)		74.90 (33–120)	0.82	0.24
Mean ACR (IQR)		13.37 (9)	0.83	0.53
Etiology of patients with pancreatitis (%)	Alcohol	70 (74.5)	0.76	0.64
	Gallstones	8 (8.5)
	High cholesterol	1 (1.1)
	Unclear	11 (11.7)
	Portal vein thrombosis	1 (1.1)
	CF gene carrier	1 (1.1)
	Medication induced	1 (1.1)
No of screening DNAs (%)	0	39 (42)	0.09	0.13
	1–2	23 (24)
	3–4	20 (21)
	5–8	12 (13)
Worst-eye retinopathy/maculopathy grade no of patients (%)	R Visit 1	R Visit 2	M Visit 1	M Visit 2
R0/M0	39 (76)	54 (63)	46 (90)	76 (88)
R1/M1	9 (18)	26 (30)	5 (10)	10 (12)
R2	2 (4)	2 (2)	–	–
R3	1 (2)	4 (5)	–	–
Change in retinopathy/maculopathy scores between visits compared with various parameters. RE=right eye, LE=left eye, RP=retinopathy progression, MP=maculopathy progression
Follow-up (n=71)	vs RE RP	vs LE RP	vs RE MP	vs LE MP
Gender	0.83	0.62	1.00	1.00
BMI (kg/m²)	0.54	0.27	0.72	0.32
Weight (kg)	0.73	0.95	0.29	0.24
Most recent HbA1c	0.21	0.76	0.87	0.88
ACR	0.50	0.14	0.29	0.30
Etiology of pancreatitis	0.71	0.32	1.00	1.00
Duration of chronic pancreatitis (years)	0.08	0.50	0.18	0.57
Duration of diabetes (years)	0.35	0.35	0.07	0.24