Table 2

Presence of CAN versus yearly change in eGFR (mL/min/1.73 m2) and UACR (%)

NOutcomesEstimate (95% CI)P value
Model 1220UACR9.905 (3.04 to 17.23)0.004
224eGFR−0.263 (−0.98 to 0.45)0.469
Model 2220UACR11.820 (4.95 to 19.14)0.001
224eGFR−0.138 (−0.850 to 0.57)0.703
Model 3219UACR11.241 (4.06 to 18.92)0.002
223eGFR0.328 (−0.38 to 1.04)0.366
Model 4217UACR7.484 (0.45 to 15.01)0.037
222eGFR0.294 (−0.461 to 1.05)0.445
Model 5194UACR7.800 (0.50 to 15.63)0.036
193eGFR0.324 (−0.486 to 1.13)0.433
Model 6167UACR7.664 (−0.093 to 16.02)0.052
165eGFR0.272 (−0.558 to 1.103)0.520
  • Model 1: unadjusted. Model 2: adjusted for age and sex. Model 3: as model 2 and additionally adjusted for duration of diabetes, Hba1c, BMI, smoking, exercise, beta-blocker use, LDL cholesterol and systolic blood pressure. Model 4: as model 3, and additionally adjusted for baseline eGFR. Model 5: as model 4 and additionally adjusted for urinary albumin excretion rate.

  • BMI, body mass index; CAN, cardiovascular autonomic neuropathy; eGFR, estimated glomerular filtration rate; LDL, low-density lipoprotein; UACR, urine albumin to creatinine ratio.