Table 1

Hoorn DCS and DiaGene cohort characteristics

DiaGeneHoorn DCS
Number of participants18151518
Female sex, % (n)46.3 (841)43.7 (664)
Age, years, mean (±SD)65.2 (10.6)64.5 (10.6)
Age of onset diabetes, years, mean (±SD)54.9 (11.7)57.3 (11.0)
BMI, kg/m2, mean (±SD)29.5 (5.5)30.4 (5.4)
HbA1c, % (SD)7.0 (1.1)6.8 (1.0)
HbA1c, mmol/mol, mean (±SD)53.3 (11.6)51 (11)
Systolic blood pressure, mm Hg, mean (±SD)141.9 (18.8)144 (19)
Diastolic blood pressure, mm Hg, mean (±SD)77.4 (9.9)76 (10)
Total cholesterol, mmol/L, mean (±SD)4.3 (0.9)4.6 (1.7)
Triglycerides, mmol/L, median (IQR)1.4 (1.0–2.0)1.6 (1.2–2.2)
HDL-c, mmol/L, mean (±SD)1.2 (0.3)1.2 (0.4)
LDL-c, mmol/L, mean (±SD)2.5 (0.8)2.6 (0.9)
Non-HDL-c, mmol/L, mean (±SD)3.1 (0.9)3.5 (1.5)
Smoking
 Never (n)425926
 Former (n)924334
 Current (n)294258
Complications
 Incident CVD, % (n case/n total)10.1 (104/1034)8.0 (97/1220)
 Prevalent CVD, % (n case/n total)34.6 (628/1669)19.0 (288/1518)
 Incident nephropathy, % (n case/n total)20.1 (244/1214)12.4 (158/1272)
 Prevalent nephropathy, % (n case/n total)20.2 (367/1621)15.5 (236/1518)
 Incident retinopathy, % (n case/n total)16.1 (219/1361)9.9 (126/1278)
 Prevalent retinopathy, % (n case/n total)16.0 (291/1714)14.2 (214/1503)
  • Details on the cohorts, including definitions and biochemical measurements, have been described elsewhere.15 16

  • BMI, body mass index; CVD, cardiovascular disease; DCS, Diabetes Care System; HbA1c, hemoglobin A1c; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol.