Table 3

Pearson correlations of M value calculated from the hyperinsulinemic-euglycemic clamp and insulin secretion (AUC) during OGTT with demographics and fasting biochemical data

	M value		OGTT-Ins-AUC		HOMA2-IR
	r	P value	r	P value	r	P value
Age	−0.161	0.218	0.182	0.167	0.1925	0.1514
Weight (kg)	0.035	0.793	0.01	0.942	−0.0195	0.8858
Height (cm)	−0.129	0.327	−0.104	0.433	−0.095	0.483
BMI (kg/m²)	0.135	0.303	0.086	0.519	0.024	0.857
Waist (cm)	0.191	0.37	0.015	0.947	0.091	0.687
SBP (mm Hg)	0.053	0.693	0.063	0.644	0.003	0.986
DBP (mm Hg)	−0.133	0.318	0.182	0.176	0.208	0.127
HR (beats per minute)	−0.232	0.079	0.144	0.284	0.461**	0.000
Hb (g/L)	−0.330*	0.011	0.198	0.137	0.223	0.098
Cre (µmol/L)	0.081	0.541	−0.171	0.195	−0.219	0.101
Albumin (g/L)	−0.284*	0.029	0.102	0.445	0.067	0.622
Platelets (×10⁹/L)	−0.165	0.212	0.001	0.431**	0.207	0.126
ALT (U/L)	−0.139	0.29	0.461**	0.0001	0.378**	0.004
AST (U/L)	0.063	0.638	0.155	0.246	0.081	0.553
T chol (mmol/L)	−0.233	0.079	0.522**	0.0001	0.254	0.059
TG (mmol/L)	−0.265*	0.044	0.531**	0.0001	0.231	0.086
HDL (mmol/L)	−0.078	0.562	−0.09	0.502	−0.109	0.423
LDL (mmol/L)	−0.186	0.162	0.503**	0.0001	0.274*	0.041
FBG (mmol/L)	−0.011	0.932	0.032	0.813	−0.059	0.674
HbA1c (%)	0.213	0.106	−0.05	0.708	−0.171	0.208
TSH (mIU/L)	−0.012	0.931	0.13	0.336	−0.205	0.133
Insulin	−0.336*	0.045	0.343*	0.041	0.370*	0.031
Region (%fat)	−0.212	0.103	0.345**	0.007	0.350**	0.008
Total mass (kg)	−0.008	0.954	0.011	0.937	−0.027	0.842
Tissue (g)	−0.013	0.923	0.027	0.838	−0.015	0.912
Fat (g)	−0.108	0.412	0.291*	0.026	0.240	0.073
Lean mass (g)	0.147	0.263	−0.213	0.105	−0.242	0.069
BMC (g)	0.03	0.818	−0.217	0.099	−0.141	0.297
Fat-free mass (g)	0.143	0.277	−0.347**	0.007	−0.243	0.069
Android (%fat)	−0.235	0.071	0.449**	0	0.346**	0.008
Gynoid (%fat)	−0.066	0.615	0.219	0.095	0.270*	0.042
A:G ratio	−0.186	0.155	0.145	0.274	0.047	0.728
Total (%fat)	−0.201	0.124	0.351**	0.006	0.352**	0.007
Glu-AUC	−0.09	0.496	0.162	0.22	0.084	0.536
Ins-AUC	−0.416**	0.001	1		0.563**	0.000
C pep-AUC	−0.219	0.096	0.244	0.063	0.284*	0.032
M value	1		−0.416**	0.001	−0.255	0.056
Adiponectin (µg/mL)	0.058	0.669	−0.301*	0.024	−0.280*	0.041
Adipsin (µg/mL)	−0.047	0.731	0.088	0.52	−0.088	0.526
CRP (ng/mL)	−0.329*	0.013	0.384**	0.004	0.434**	0.001
TNFRSF1B (ng/mL)	0.036	0.789	0.033	0.805	0.133	0.332
sRAGE (ng/mL)	−0.102	0.442	−0.072	0.586	−0.212	0.114
Oxidized LDL	−0.059	0.658	0.257*	0.05	0.154	0.254
TAC (U/L)	−0.171	0.194	0.159	0.229	−0.108	0.423
GPX-1 (ng/mL)	0.003	0.984	−0.08	0.551	−0.090	0.509
TIMP-1 (ng/mL)	−0.202	0.132	0.087	0.526	0.161	0.245
PIIINP (µg/mL)	0.196	0.144	−0.1	0.461	−0.020	0.888
HA (ng/mL)	−0.278*	0.036	−0.102	0.455	−0.129	0.354
ELF score	−0.167	0.217	−0.246	0.07	−0.135	0.336
NAFLD score	0.233	0.138	−0.367*	0.018	−0.235	0.149

Region (%fat) is % of fat present in the legs and trunk region. Tissue (g) is total body weight minus bone mineral content.
*p<0.05 and **p<0.01.
A:G, android to gynoid % fat ratio; ALT, alanine transaminase; AST, aspartate aminotransferase; AUC, area under the curve; BMC, bone marrow concentration; BMI, body mass index; C pep-AUC, C peptide area under curve; Cre, creatinine; CRP, C reactive protein; DBP, diastolic blood pressure; ELF, enhanced liver fibrosis; FBG, fasting blood glucose; Glu-AUC, glucose area under curve; GPX-1, glutathione peroxidase 1; HA, hyaluronic acid; Hb, hemoglobin; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; HOMA2-IR, Homeostatic Model Assessment 2 for Insulin Resistance; HR, heart rate; Ins-AUC, insulin area under curve; LDL, low-density lipoprotein; M value, whole-body glucose disposal rate; NAFLD, non-alcoholic fatty liver disease; OGTT, oral glucose tolerance test; PIIINP, procollagen III amino-terminal peptide; SBP, systolic blood pressure; sRAGE, soluble receptor for advanced glycation end products; TAC, total antioxidant capacity; T chol, total cholesterol; TG, triglycerides; TIMP-1, tissue inhibitor of metalloproteinase 1; TNFRSF1B, soluble tumor necrosis factor alpha receptor 2B; TSH, thyroid stimulating hormone.