Causal associations between genetically determined insomnia and T2DM
| Trait | Method | nSNP | OR | 95% CI | P value | MR-Egger intercept P |
| Insomnia–T2DM | MR Egger | 127 | 1.115 | 0.852 to 1.459 | 0.429 | 0.859 |
| Weighted median | 127 | 1.187 | 1.122 to 1.256 | 0.000 | ||
| Inverse variance weighted | 127 | 1.142 | 1.072 to 1.216 | 0.000 | ||
| Simple mode | 127 | 1.244 | 1.044 to 1.482 | 0.016 | ||
| Weighted mode | 127 | 1.221 | 1.049 to 1.422 | 0.011 |
The genetically predicted insomnia has a causal association with T2DM (in bold).
MR, Mendelian randomization; SNP, single-nucleotide polymorphism; T2DM, type 2 diabetes mellitus.