Table 2

Causal associations between genetically determined insomnia and T2DM

TraitMethodnSNPOR95% CIP valueMR-Egger intercept P
Insomnia–T2DMMR Egger1271.1150.852 to 1.4590.4290.859
Weighted median1271.1871.122 to 1.2560.000
Inverse variance weighted1271.1421.072 to 1.2160.000
Simple mode1271.2441.044 to 1.4820.016
Weighted mode1271.2211.049 to 1.4220.011
  • The genetically predicted insomnia has a causal association with T2DM (in bold).

  • MR, Mendelian randomization; SNP, single-nucleotide polymorphism; T2DM, type 2 diabetes mellitus.