Table 4

Causal association between genetically determined potential mediators and T2DM

TraitMethodnSNPOR95% CIP valueMR-Egger intercept P
BMI–T2DMMR Egger3323.1712.546 to 3.9480.0000.451
Weighted median3322.9322.652 to 3.2410.000
Inverse variance weighted3322.9322.706 to 3.1760.000
Simple mode3322.9962.213 to 4.0550.000
Weighted mode3322.9962.303 to 3.8960.000
Waist-to-hip ratio–T2DMMR Egger205.0620.948 to 27.0290.0740.066
Weighted median202.1061.693 to 2.6190.000
Inverse variance weighted202.2711.651 to 3.1230.000
Simple mode202.3431.466 to 3.7460.002
Weighted mode202.3841.581 to 3.5950.001
Body fat percentage–T2DMMR Egger1952.8991.287 to 6.5310.0110.722
Weighted median1953.2002.758 to 3.7130.000
Inverse variance weighted1952.5152.026 to 3.1210.000
Simple mode1953.3982.132 to 5.4150.000
Weighted mode1953.3982.128 to 5.4240.000
  • Higher BMI, waist-to-hip ratio and body fat percentage levels are causally associated with increased risk of T2DM (in bold).

  • BMI, body mass index; MR, Mendelian randomization; SNP, single-nucleotide polymorphism; T2DM, type 2 diabetes mellitus.