Trait | Method | nSNP | Beta | SE | P value | MR-Egger intercept P |
BMI | MR Egger | 150 | 0.030 | 0.053 | 0.570 | 0.379 |
Weighted median | 150 | 0.061 | 0.008 | 0.000 | ||
Inverse variance weighted | 150 | 0.075 | 0.014 | 0.000 | ||
Simple mode | 150 | 0.067 | 0.022 | 0.002 | ||
Weighted mode | 150 | 0.057 | 0.016 | 0.001 | ||
Waist-to-hip ratio | MR Egger | 120 | −0.026 | 0.053 | 0.618 | 0.270 |
Weighted median | 120 | 0.038 | 0.017 | 0.026 | ||
Inverse variance weighted | 120 | 0.031 | 0.012 | 0.011 | ||
Simple mode | 120 | 0.080 | 0.047 | 0.090 | ||
Weighted mode | 120 | 0.056 | 0.045 | 0.215 | ||
Body fat percentage | MR Egger | 149 | 0.006 | 0.039 | 0.880 | 0.123 |
Weighted median | 149 | 0.055 | 0.008 | 0.000 | ||
Inverse variance weighted | 149 | 0.064 | 0.011 | 0.000 | ||
Simple mode | 149 | 0.070 | 0.021 | 0.001 | ||
Weighted mode | 149 | 0.061 | 0.019 | 0.002 | ||
HbA1c | MR Egger | 117 | 0.036 | 0.263 | 0.893 | 0.949 |
Weighted median | 117 | 0.048 | 0.088 | 0.585 | ||
Inverse variance weighted | 117 | 0.019 | 0.061 | 0.751 | ||
Simple mode | 117 | −0.186 | 0.246 | 0.450 | ||
Weighted mode | 117 | −0.039 | 0.188 | 0.836 | ||
Fasting blood glucose | MR Egger | 139 | −0.070 | 0.082 | 0.394 | 0.476 |
Weighted median | 139 | −0.014 | 0.030 | 0.638 | ||
Inverse variance weighted | 139 | −0.014 | 0.021 | 0.513 | ||
Simple mode | 139 | −0.009 | 0.086 | 0.912 | ||
Weighted mode | 139 | 0.005 | 0.082 | 0.951 | ||
Fasting blood insulin | MR Egger | 139 | −0.109 | 0.098 | 0.268 | 0.239 |
Weighted median | 139 | −0.013 | 0.035 | 0.702 | ||
Inverse variance weighted | 139 | 0.003 | 0.025 | 0.908 | ||
Simple mode | 139 | −0.096 | 0.110 | 0.385 | ||
Weighted mode | 139 | −0.066 | 0.097 | 0.495 |
Insomnia is causally associated with BMI and body fat percentage (in bold).
BMI, body mass index; MR, Mendelian randomization; SNP, single-nucleotide polymorphism.