ORs (95% CI) for prevalent pre-diabetes (vs normal glucose tolerance) and prevalent type 2 diabetes (vs no type 2 diabetes) per SD increase of active plasma renin concentration, aldosterone and ARR
| Prevalent pre-diabetes (yes: n=488; no: n=2110) | P value | Prevalent type two diabetes (yes: n=333; no: n=2598) | P value | |
| Renin | 1.20 (1.07 to 1.35) | 0.002 | 1.25 (1.10 to 1.43) | <0.001 |
| Aldosterone | 1.10 (0.98 to 1.24) | 0.095 | 1.04 (0.91 to 1.19) | 0.547 |
| ARR | 0.92 (0.82 to 1.03) | 0.151 | 0.82 (0.72 to 0.93) | 0.002 |
Bold print indicates significance after correction for multiple testing using the Bonferroni method (p<0.008 (0.05 รท 6)).
The logistic regression models were adjusted for sex, age, BMI, arterial hypertension, eGFR, potassium, use of ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics and calcium channel blockers.
ARR, aldosterone-to-renin ratio; BMI, body mass index; eGFR, estimated glomerular filtration rate.