ORs (95% CI) for incident pre-diabetes/type 2 diabetes (vs non-progressors to pre-diabetes/type 2 diabetes from normal glucose tolerance) and incident type 2 diabetes (vs non-progressors to type 2 diabetes from normal glucose tolerance or pre-diabetes) per SD increase of active plasma renin concentration, aldosterone and ARR
| Incident pre-diabetes/type 2 diabetes (yes: n=283; no: n=1260) | P value | Incident type 2 diabetes (yes: n=130; no: n=1704) | P value | |
| Renin | 1.05 (0.9–1.22) | 0.538 | 1.12 (0.92–1.36) | 0.257 |
| Aldosterone | 1.00 (0.86–1.16) | 0.993 | 0.91 (0.74–1.11) | 0.343 |
| ARR | 0.97 (0.83–1.13) | 0.660 | 0.87 (0.71–1.05) | 0.152 |
Significance level after correction for multiple testing using the Bonferroni method (p<0.008 (0.05 ÷ 6)).
The logistic regression models were adjusted for sex, age, BMI, arterial hypertension, eGFR, potassium, use of ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics and calcium channel blockers.
ARR, aldosterone-to-renin ratio; BMI, body mass index; eGFR, estimated glomerular filtration rate.