N events/N at risk | HR * (95% CI) | P value | |
Fasting plasma insulin, pmol/L | 352/2819 | 1.36 (1.21 to 1.52) | <0.0001 |
2h-insulin, pmol/L | 344/2750 | 1.33 (1.23 to 1.44) | <0.0001 |
Fasting plasma glucose, mg/dL | 350/2792 | 2.76 (2.46 to 3.11) | <0.0001 |
2h-glucose, mg/dL | 345/2755 | 1.91 (1.74 to 2.09) | <0.0001 |
Hemoglobin A1C, % (mmol/mol) | 254/2043 | 1.27 (1.16 to 1.39) | <0.0001 |
Bold indicates p<0.05.
*Models were adjusted for age, sex, current smoking, waist circumference, hypertension status, total/HDL cholesterol ratio, triglyceride levels, lipid-lowering medication, and the Physical Activity Index. Fasting plasma insulin was log-transformed. All glycemic markers were standardized (mean=0, SD=1). Thus, the HRs are given per 1-SD increment in the glycemic marker.
2h, 2-hour; HR, Hazard Ratio.