Characteristics of CGM-assessed and self-reported hypoglycemia in type 2 diabetes according to treatment
| Variable | Median (IQR) for continuous variables, n (%) for proportions | ||
| Metformin group | SU group | Insulin group | |
| Number | 28 | 100 | 51 |
| Female, n (%) | 18 (64.3) | 57 (57.0) | 31 (60.8) |
| Age, years | 56.5 (49.5–61.5) | 55.5 (50.0–62.0) | 55.0 (49.0–64.0) |
| Diabetes duration, years | 5.0 (2.0–8.0) | 6.0 (3.0–9.0) | 10.0 (8.0–17.0) |
| BMI, kg/m2 | 26.9 (24.2–29.9) | 26.7 (23.7–30.1) | 25.8 (23.1–30.2) |
| eGFR | 113.4 (96.8–123.7) | 112.8 (93.8–121.0) | 110.8 (92.3–121.8) |
| Renal impairment, n (%) | 0 (0) | 6 (6.0) | 4 (7.8) |
| Glycemic control | |||
| CGM duration | 14 (13–14) | 14 (13–14) | 14 (13–14) |
| Average CGM glucose (mmol/L) | 6.8 (5.4–9.9) | 8.5 (7.0–12.0) | 10.1 (8.2–14.5) |
| HbA1c (%) | 6.4 (5.8–8.0) | 8.2 (6.9–9.6) | 9.8 (8.2–11.3) |
| HbA1c (mmol/mol) | 46 (40–64) | 66 (52–83) | 84 (67–102) |
| Fasting glucose | 7.2 (5.5–10.2) | 8.2 (6.2–10.7) | 9.3 (7.0–12.3) |
| Glucose variability (cv) | 0.29 (0.26–0.33) | 0.34 (0.29–0.39) | 0.39 (0.33–0.47) |
| SD | 2.06 (1.65–2.93) | 3.16 (2.59–3.85) | 4.0 (3.3–5.2) |
| Percent time spent in optimal range | 78.1 (55.3–86.4) | 60.1 (33.8–73.9) | 40.1 (22.2,–55.4) |
| Percent time above 10 | 10.9 (1.3–35.3) | 31.9 (14.3–66.0) | 49.3 (30.8–74.2) |
| CGM hypoglycemia per week | |||
| Episodes <3 mmol/L | 1 (0–2.3) | 0.5 (0–3.0) | 2 (0–6.0) |
| Total time/week <3 mmol/L, min | 39.2 (0–174.8) | 17.0 (0–229.3) | 127.5 (0–637.5) |
| Per cent time <3 mmol/L (%) | 0.39 (0, 1.74) | 0.17 (0, 2.26) | 1.27 (0, 6.42) |
| Self-reported hypoglycemia, n (%) | |||
| History of hypoglycemia events, n (%) | 7 (25.0) | 28 (28.0) | 23 (45.1) |
| Hospitalized for hypoglycemia in the previous 12 months, yes | 1 (3.6) | 3 (3.0) | 6 (11.8) |
| Hospitalized for hypoglycemia in the previous 12 months, % (95% CI) | 3.6 (0.1 to 18.3) | 3.0 (0.6 to 8.5) | 11.8 (4.4 to 23.9) |
BMI, body mass index; CGM, continuous glucose monitoring; eGFR, estimated glomerular filtration rate; HbA1c, glycated haemoglobin; SU, sulphonylurea.