Table 1

Characteristics of the included studies

Study author and year	Trial registration details	Type of design	Participants (n)	Age category	C-L control algorithm	24 hours or overnight	Comparator	Study duration (weeks)
Thabit et al, 201512	NCT01961622	Crossover	33	Adult	MPC	24 hours	SAP	12
Thabit et al, 201512	NCT01778348	Crossover	25	Children	MPC	Overnight	SAP	12
Kropff et al, 201515	NCT02153190	Crossover	32	Adult	MPC	Overnight	SAP	8
Tauschmann et al, 201813	NCT02523131	Parallel	C-L (46), control (40)	Both	MPC	24 hours	SAP	12
Benhamou et al, 201921	NCT02987556	Crossover	63	Adult	Diabeloop	24 hours	SAP or PLGS	12
Brown et al, 201918	NCT03563313	Parallel	C-L (112), control (56)	Both	Control-IQ	24 hours	SAP	26
Brown et al, 202019	NCT03591354	Parallel	C-L (54), control (55)	Both	Control-IQ	24 hours	PLGS	13
Breton et al, 202020	NCT03844789	Parallel	C-L (78), control (23)	Children	Control-IQ	24 hours	SAP	16
Kovatchev et al, 202017	NCT02985866	Parallel	C-L (78), control (23)	Both	Control-IQ	24 hours	SAP	13
Kovatchev et al, 202016	NCT02679287	Crossover	80	Adult	InControl	Overnight	SAP	8
McAuley et al, 202014	ACTRN12617000520336	Parallel	C-L (61), control (59)	Both	PID	24 hours	MDI or insulin pump	26

C-L, closed loop; MDI, multiple daily injections; MPC, model predictive control; PID, proportional, integral, differential algorithm; PLGS, predictive low-glucose suspend; SAP, sensor-augmented pump.