Acute DKA experiments. Biochemical values in each comparison group at the time of initiation of DKA treatment, mean (SD)
| NG control | HG control | DKA | DKA-minocycline | DKA-TRAM-34 | |
| n=12 | n=12 | n=14 | n=10 | n=10 | |
| pH* | 7.38 (0.05) | 7.35 (0.05) | 6.83 (0.24) | 6.85 (0.13) | 6.80 (0.10) |
| Glucose (mg/dL/ mmol/L)† | 143 (14) | 481 (203) | 440 (140) | 439 (106) | 390 (44) |
| Sodium (mEq/L) | 139 (1) | 136 (2) | 136 (6) | 136 (3) | 135 (4) |
| Bicarbonate (mEq/L)‡ | 32 (2) | 30 (4) | 12 (3) | 11 (2) | 11 (3) |
| BUN (mg/dL/ mmol/L)§ | 14 (2) | 17 (4) | 61 (44) | 48 (33) | 30 (13) |
*p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.
†p<0.01 for pairwise comparisons of all DKA groups versus NG control and HG control versus NG control.
‡ p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.
§p<0.05 for pairwise comparisons of DKA versus NG control and DKA-minocycline versus NG control.
BUN, blood urea nitrogen; DKA, diabetic ketoacidosis; HG, hyperglycemic; NG, normoglycemic; TRAM-34, triarylmethane-34.