Table 1

Acute DKA experiments. Biochemical values in each comparison group at the time of initiation of DKA treatment, mean (SD)

NG controlHG controlDKADKA-minocyclineDKA-TRAM-34
n=12n=12n=14n=10n=10
pH*7.38 (0.05)7.35 (0.05)6.83 (0.24)6.85 (0.13)6.80 (0.10)
Glucose (mg/dL/ mmol/L)†143 (14)481 (203)440 (140)439 (106)390 (44)
Sodium (mEq/L)139 (1)136 (2)136 (6)136 (3)135 (4)
Bicarbonate (mEq/L)‡32 (2)30 (4)12 (3)11 (2)11 (3)
BUN (mg/dL/ mmol/L)§14 (2)17 (4)61 (44)48 (33)30 (13)
  • *p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.

  • †p<0.01 for pairwise comparisons of all DKA groups versus NG control and HG control versus NG control.

  • ‡ p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.

  • §p<0.05 for pairwise comparisons of DKA versus NG control and DKA-minocycline versus NG control.

  • BUN, blood urea nitrogen; DKA, diabetic ketoacidosis; HG, hyperglycemic; NG, normoglycemic; TRAM-34, triarylmethane-34.