Table 2

Long-term experiments. Biochemical values in each comparison group at the time of initiation of DKA treatment in the juvenile period, mean (SD)

HG controlDKADKA-minocyclineDKA-TRAM-34
n=16n=16n=10n=10
pH*7.33 (0.03)6.77 (0.16)6.92 (0.08)6.84 (0.05)
Glucose (mg/dL/ mmol/L)†568 (127)432 (86)359 (35)445 (151)
Sodium (mEq/L)134 (4)134 (4)130 (4)132 (11)
Bicarbonate (mEq/L)‡29 (3)11 (3)10 (1)9 (2)
BUN (mg/dL/mmol/L)§19 (5)55 (29)26 (5)62 (44)
  • *p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.

  • †p<0.01 for pairwise comparisons of all DKA groups versus NG control and HG control versus NG control.

  • ‡ p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.

  • §p<0.05 for pairwise comparisons of DKA versus NG control and DKA-minocycline veesus NG control.

  • BUN, blood urea nitrogen; DKA, diabetic ketoacidosis; HG, hyperglycemic; NG, normoglycemic; TRAM-34, triarylmethane-34.