Table 1

Hypoglycemia values as per varying thresholds for hypoglycemia

	Patients	Data points	3.9 mmol/L (70 mg/dL)			3.5 mmol/L (63 mg/dL)				3.0 mmol/L (54 mg/dL)
	Patients	Data points	% time hypo	Hypos/ day	Mean duration (min)	% time hypo	P value	Hypos/ day	Mean duration (min)	% time hypo	Hypos/ day	Mean duration (min)
All	63	3 397 713	6.90	2.4	42.4	3.26		1.3	36.4	1.21	0.5	34.6
Mutation positive	43	1 919 470	6.39	2.1	44.1	3.01	<0.001	1.2	36.8	1.11	0.5	33.3
Mutation negative	20	1 478 243	7.56	2.7	40.6	3.58	<0.001	1.4	36.0	1.35	0.5	36.1
On CHI medications	49	2 818 276	5.53	1.9	42.6	2.54	<0.001	1.0	36.0	0.91	0.4	32.7
Off CHI medications	14	579 437	13.6	4.7	41.8	6.74	<0.001	2.6	37.2	2.65	1.0	38.3
All (non-ADA)	63	3 397 713	7.36	4.1	25.9	3.61		2.4	21.5	1.40	19.1	19.1

P value=p value for difference in % time hypo (<3.5mmol/L) between subgroups, calculated via Χ² test. Mean length is presented in minutes.
Mutation positive=any known CHI-causing mutation demonstrated.
Mutation negative=either CHI gene panel negative or not done.
Hypos=hypoglycemic episodes.
All values are provided as per ADA criteria unless otherwise specified.
ADA, American Diabetes Association; CHI, congenital hyperinsulinism.