Table 2

Adjusted models HRs of A1c TIR predicting incident microvascular complications

Main predictorMicrovascular
(n=74 016)
Retinopathy
(n=235 580)
Neuropathy
(n=222 274)
Nephropathy
(n=168 616)
A1c TIR
 80% to 100%1.001.001.001.00
 60% to <80%1.03* (1.00–1.07)1.03 (1.00–1.06)1.07* (1.04–1.10)1.03 (1.00–1.05)
 40% to <60%1.02 (0.99–1.05)1.04* (1.01–1.07)1.05* (1.02–1.08)1.05* (1.02–1.08)
 20% to <40%1.03* (1.00–1.06)1.04* (1.01–1.07)1.05* (1.02–1.08)1.04* (1.02–1.07)
 0% to <20%1.04* (1.02–1.07)1.05* (1.02–1.08)1.04* (1.01–1.06)1.06* (1.04–1.09)
A1c SD1.01 (0.98–1.04)0.92* (0.90–0.94)0.95* (0.93–0.97)1.08* (1.05–1.10)
A1c mean1.09* (1.08–1.11)1.17* (1.15–1.18)1.10* (1.09–1.11)1.08* (1.07–1.09)
  • *P<0.05.

  • A1c, hemoglobin A1c; TIR, time in range.