Table 3

Adjusted HRs of A1c TIR predicting incident macrovascular complications

Main predictorMacrovascular
(n=89 625)
Cardiovascular
(n=122 135)
Cerebrovascular
(n=277 234)
Peripheral vascular (n=228 583)
A1c TIR****
 80% to 100%1.001.001.001.00
 60% to <80%1.05* (1.02–1.08)1.02 (0.99–1.05)1.05* (1.02–1.08)1.09* (1.06–1.13)
 40% to <60%1.03* (1.00–1.06)1.01 (0.99–1.04)1.08* (1.05–1.11)1.09* (1.05–1.12)
 20% to <40%1.05* (1.02–1.08)1.05* (1.02–1.08)1.07* (1.04–1.10)1.09* (1.06–1.12)
 0% to <20%1.08* (1.05–1.11)1.08* (1.05–1.11)1.09* (1.07–1.12)1.12* (1.09–1.15)
A1c SD1.00 (0.98–1.03)1.00 (0.98–1.02)0.98 (0.97–1.00)0.99 (0.97–1.01)
A1c mean1.05* (1.04–1.06)1.05* (1.04–1.06)1.08* (1.07–1.09)1.11* (1.10–1.12)
  • *P<0.05.

  • A1c, hemoglobin A1c; TIR, time in range.