Comparability of patients with type 2 diabetes between the IMEDS Distributed Database and other data sources commonly used for diabetes research: comorbidities and health services utilization
| IMEDS-DD | Other databases | References | |||
| Source | Data | Study period | |||
| Comorbid conditions in patients with type 2 diabetes | |||||
| Combined comorbidity score23 (mean, SD) | 3.6 (4.0) | 2.4 (2.1)* | Weng et al13 | IBM MarketScan Research Databases | 2015 |
| 2.5 (1.7)* | Tang et al15 | CPRD | 2012–2014 | ||
| Cardiovascular disease | 44.7% | 45.2% | Weng et al13 | IBM MarketScan Research Databases | 2015 |
| Heart failure | 16.9% | 9%–22% | Dunlay et al17 | Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement from the American Heart Association and the Heart Failure Society of America | 2019 |
| 11.2% | Bailey et al12 | NHANES | 1999–2012 | ||
| Moderate-to-severe chronic kidney disease | 20.2% | 24.9% | CDC National Diabetes Statistics Report10 | NHANES | 2013–2016 |
| 24.1% | Iglay et al18 | Quintiles Electronic Medical Record (EMR) research database (Q-EMR) | 2014–2015 | ||
| 22% (20.4%–23.5%) | Bailey et al12 | NHANES | 1999–2012 | ||
| 22.3%–23.5% | McGurnaghan et al16 | SCI-Diabetes | 2014–2016 | ||
| 18.9% | Tang et al15 | CPRD | 2012–2014 | ||
| Neuropathy | 25.4% | 16.2% | Pantalone et al19 | Cleveland Clinic electronic health record system | 2008–2013 |
| 28.5% | Gregg et al20 | NHANES | 1999–2000 | ||
| Retinopathy | 10.9% | 11.7% | CDC National Diabetes Statistics Report10 | Behavioral Risk Factor Surveillance System | 2018 |
| 12.1% | Weng et al13 | IBM MarketScan Research Databases | 2015 | ||
| Health services utilization in patients with type 2 diabetes | |||||
| Number of unique antihyperglycemics (mean, SD) | 1.3 (1.4) | 42.2% on monotherapy | Bachmann et al22 | National Patient-Centered Clinical Research Network (PCORnet) | 2012–2017 |
| 40.6% on monotherapy | Iglay et al18 | Q-EMR | 2014–2015 | ||
| Number of unique non-antihyperglycemics (mean, SD) | 12.4 (9.0) | 8.3 (7.0)–10.1 (8.3) | Mehta et al21 | Q-EMR linked to administrative claims from the Truven Health MarketScan database | 2012 |
| Number of inpatient hospital encounters (mean, SD) | 0.7 (1.7) | 0.2 (0.5)– 0.4 (0.8) | |||
| Number of ambulatory encounters (mean, SD) | 36.6 (41.1) | 17.8 (18.6)–27.5 (25.0) | |||
*Charlson Comorbidity Index.24
CDC, Centers for Disease Control and Prevention; CPRD, Clinical Practice Research Datalink; IMEDS, Innovation in Medical Evidence and Development Surveillance; IMEDS-DD, IMEDS Distributed Database; NHANES, National Health and Nutrition Examination Survey; SCI-Diabetes, Scottish Care Information-Diabetes system.