Table 1

CpGs associated with cross-sectional HbA1c at FDR of <20% in the EDC study

ID	Chr	Location	CpG position	Gene symbol	Location relative to gene	β per 1% HbA1c	SE	P value	bacon-adjusted FDR*
cg19693031	1	Open Sea	145 441 552	*TXNIP*	3′UTR	−0.016	0.0025	2.67E-10	0.0001
cg21534330	17	S. Shore	80 209 281	*CSNK1D*	Body	−0.009	0.0014	1.15E-09	0.0001
cg21857724	2	Open Sea	231 523 609	n/a	Intergenic	−0.005	0.0010	3.31E-07	0.0462
cg03827739	10	Open Sea	75 401 754	MYOZ1	TSS1500	0.004	0.0007	8.69E-07	0.1506
cg14209562	5	Open Sea	177 880 534	COL23A1	Body	−0.006	0.0013	8.93E-07	0.0800
cg19225602	11	N.Shelf	75 269 316	n/a	Intergenic	−0.003	0.0007	2.18E-06	0.0800
cg27629986	2	Open Sea	219 585 157	TTLL4	5′UTR	−0.003	0.0007	2.23E-06	0.1320
cg06053844	6	Open Sea	3 870 115	n/a	Intergenic	−0.003	0.0007	2.83E-06	0.1320
cg24236935	2	Open Sea	20 690 701	n/a	Intergenic	−0.004	0.0009	3.07E-06	0.1320
cg18422654	14	Open Sea	23 905 273	MYH7	TSS1500	−0.003	0.0006	3.40E-06	0.1325
cg11069395	12	N.Shore	53 272 002	n/a	IntergeniIc	−0.004	0.0008	3.59E-06	0.1325
cg21513463	12	Open Sea	131 076 481	n/a	Intergenic	−0.002	0.0004	3.80E-06	0.1325
cg17238830	5	Open Sea	76 256 017	CRHBP	Body	−0.005	0.0011	4.34E-06	0.1325
cg14051336	5	S.Shelf	149 515 317	PDGFRB	Body	−0.004	0.0008	4.83E-06	0.1325
cg03167712	6	Open Sea	83 587 490	n/a	Intergenic	−0.005	0.0010	5.71E-06	0.1325
cg18640098	5	Open Sea	9 888 660	LOC285692	Body	−0.004	0.0009	9.60E-06	0.1325
cg09847325	1	Open Sea	4 842 442	AJAP1	3′UTR	−0.004	0.0009	1.04E-05	0.1339
cg09905117	19	Open Sea	47 454 619	ARHGAP35	Body	−0.004	0.0009	1.05E-05	0.1410
cg03156851	13	Open Sea	88 675 293	n/a	Intergenic	−0.006	0.0013	1.15E-05	0.1506

Results of linear models adjusted for type 1 diabetes duration, sex, pack years of smoking, estimated cell type composition variables, and plate/run indicator, well position, GCT bisulfite score, DNA extraction method, study visit of DNA collection, first two principal components of ancestry from genotyping arrays, and two surrogate variables from sva, sorted by ascending p value.
*Bolded rows are significant at the Bonferroni-adjusted threshold, p<7.3×10⁻⁸.
CpG, 5′-cytosine-phosphate-guanine-3′; CSNK1D, Casein Kinase 1 Isoform Delta; EDC, Epidemiology of Diabetes Complications; FDR, false discovery rate; n/a, not applicable; TXNIP, Thioredoxin-Interacting Protein.