Table 2

Crude and adjusted ORs with associated 95% CIs for cancer in 233 patients with T2DM

Variables	Crude OR			Adjusted OR†
Variables	OR	95% CI	P value	OR	95% CI	P value
Sex (female vs male)	3.488	1.276 to 9.536	0.015*	6.704	1.007 to 44.649	0.049*
Age (years)	1.034	0.990 to 1.079	0.131	1.008	0.950 to 1.069	0.794
Ever smoking	0.623	0.216 to 1.794	0.380	3.408	0.538 to 21.577	0.193
Ever drinking	0.340	0.076 to 1.520	0.158	1.380	0.169 to 11.302	0.764
Systolic blood pressure (mm Hg)	1.010	0.983 to 1.039	0.465	0.999	0.960 to 1.040	0.971
Diastolic blood pressure (mm Hg)	1.007	0.961 to 1.056	0.764	1.005	0.939 to 1.076	0.877
Triglyceride (mmol/L)	0.966	0.728 to 1.282	0.810	0.999	0.345 to 2.892	0.999
Total cholesterol (mmol/L)	0.947	0.666 to 1.348	0.763	0.432	0.026 to 7.121	0.558
HDL-cholesterol (mmol/L)	0.577	0.116 to 2.865	0.501	0.734	0.021 to 26.038	0.865
LDL-cholesterol (mmol/L)	1.033	0.646 to 1.652	0.892	2.355	0.132 to 41.913	0.560
Fasting plasma glucose (mmol/L)	1.034	0.895 to 1.194	0.654	1.136	0.919 to 1.405	0.239
HbA1c (%)	0.911	0.734 to 1.132	0.401	0.810	0.580 to 1.130	0.215
Blood uric acid (mmol/L)	0.999	0.994 to 1.004	0.752	0.998	0.992 to 1.004	0.567
Diabetes treatment (%)
Oral hypoglycemic medications use	0.922	0.317 to 2.680	0.881	0.996	0.242 to 4.093	0.995
Insulin use	0.242	0.054 to 1.077	0.062	0.256	0.051 to 1.290	0.099
Weight (kg)	0.964	0.925 to 1.004	0.079	0.938	0.877 to 1.003	0.062
BMI (kg/m²)	0.954	0.832 to 1.094	0.500	0.847	0.702 to 1.021	0.082
BMI category (kg/m²)
Underweight or normal weight (<23.0)	1.000			1.000
Overweight (23.0–24.9)	2.195	0.656 to 7.350	0.202	1.640	0.319 to 8.415	0.554
Obesity (≥25.0)	0.956	0.292 to 3.137	0.941	0.584	0.127 to 2.687	0.490
Trend test			0.832			0.296
NAFLD (yes vs no)	4.364	1.592 to 11.961	0.004*	5.969	1.349 to 26.413	0.019*
Interaction test: NAFLD* BMI category			0.692			0.586
FIB-4 score	1.235	0.674 to 2.261	0.495	0.958	0.484 to 1.896	0.901

*P<0.05.
†Adjusted for sex, age, ever smoking, ever drinking, systolic and diastolic blood pressure, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol, HbA1c, serum uric acid, oral hypoglycemic medications and insulin use, BMI and NAFLD.
BMI, body mass index; FIB-4, fibrosis-4; HbA1c, glycosylated hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NAFLD, non-alcoholic fatty liver disease; T2DM, type 2 diabetes mellitus.