Detailed results of the difference in echocardiographic outcomes
| Echocardiographic parameters related to LVDD | No of studies | WMD (95% CI) | z | P value | I2 | P value (heterogeneity) |
| E/A ratio | 10 | −0.0493 (−0.0827 to −0.0158) | −2.89 | 0.0039 | 38.1% | 0.1042 |
| Peak E velocity (E) | 7 | 1.7752 (−1.1352 to 4.6856) | 1.20 | 0.2319 | 70.1% | 0.0027 |
| e’ | 5 | −1.3650 (−1.8167 to −0.9132) | −5.92 | <0.0001 | 49.9% | 0.0920 |
| Peak A velocity (A) | 7 | 2.1243 (0.1131 to 4.1355) | 2.07 | 0.0384 | 0.0% | 0.9879 |
| E/e’ ratio | 8 | 2.1016 (1.7175 to 2.4857) | 10.72 | <0.0001 | 46.2% | 0.0717 |
| Deceleration time | 6 | 0.4633 (−8.7358 to 9.6624) | 0.10 | 0.9214 | 47.4% | 0.0908 |
| LAVImax | 5 | 2.5761 (1.3404 to 3.8118) | 4.09 | <0.0001 | 62.5% | 0.0308 |
| LVMI | 9 | 3.7194 (1.9658 to 5.4730) | 4.16 | <0.0001 | 0.0% | 0.8706 |
Bold font represents significant differences (p value <0.05).
e’, mean mitral annular diastolic velocity ; LAVImax, left atrial maximum volume index; LVDD, left ventricular diastolic dysfunction; LVMI, left ventricular mass index; WMD, weighted mean difference.