Association of weighted and unweighted genetic risk scores with log-transformed hsCRP in patients with type 2 diabetes
| Variables | Log hsCRP | |||||
| Crude model | Adjusted model | |||||
| n | Mean±SD | β (SE) | F value | β (SE) | F value | |
| Unweighted genetic risk score, per 1 point | 2332 | 0.25±1.05 | 0.11 (0.01)* | 75.54* | 0.11 (0.01)* | 39.05* |
| Tertile 1: 0~2 | 812 | 0.03±1.06 | ref | 33.14* | ref | 36.12* |
| Tertile 2: 3~4 | 766 | 0.30±1.05 | 0.27 (0.05)* | 0.23 (0.05)* | ||
| Tertile 3: >5 | 754 | 0.45±0.99 | 0.42 (0.05)* | 0.42 (0.05)* | ||
| Weighted genetic risk score, per 1 point | 2332 | 0.25±1.05 | 0.42 (0.05)* | 74.72* | 0.43 (0.04)* | 40.76* |
| Tertile 1: 0~0.56 | 812 | 0.03±1.06 | ref | 32.83* | ref | 37.4* |
| Tertile 2: 0.57~1.03 | 759 | 0.30±1.05 | 0.27 (0.05)* | 0.24 (0.05)* | ||
| Tertile 3: >1.03 | 761 | 0.44±0.99 | 0.42 (0.05)* | 0.39 (0.05)* | ||
Multivariate model adjusting for covariates that satisfy the MR assumption 2.
*p<0.001.
hsCRP, high-sensitivity C-reactive protein.