Characteristics of study subjects according to tertile subgroups of weighted and unweighted genetic risk score (GRS) (n=2332)
| Characteristic | GRS | Weigh-GRS | ||||||
| Tertile 1 (n=812) | Tertile 2 Yes (n=766) | Tertile 3 (n=754) | P value | Tertile 1 (n=812) | Tertile 2 (n=759) | Tertile 3 (n=761) | P value | |
| Age (years) | 58.52±7.59 | 58.45±8.02 | 58.82±7.39 | 0.60 | 58.52±7.59 | 58.45±8.01 | 58.82±7.41 | 0.60 |
| Sex | 0.59 | 0.48 | ||||||
| Men | 354 (43.60) | 328 (42.82) | 342 (45.36) | 354 (43.6) | 323 (42.56) | 347 (45.60) | ||
| Women | 458 (56.40) | 438 (57.18) | 412 (54.64) | 458 (56.4) | 436 (57.44) | 414 (54.40) | ||
| Education level | 0.43 | 0.36 | ||||||
| ≤6 | 113 (13.92) | 123 (16.06) | 116 (15.38) | 113 (13.92) | 123 (16.21) | 116 (15.24) | ||
| 7~12 | 358 (44.09) | 331 (43.21) | 351 (46.55) | 358 (44.09) | 326 (42.95) | 356 (46.78) | ||
| ≥13 | 341 (42.00) | 312 (40.73) | 287 (38.06) | 341 (42.00) | 310 (40.84) | 289 (37.98) | ||
| Marriage status | ||||||||
| Married | 611 (75.25) | 576 (75.2) | 602 (79.84) | 0.05 | 611 (75.25) | 570 (75.10) | 608 (79.89) | 0.04 |
| Behaviors | ||||||||
| Physical activity | 420 (51.72) | 393 (51.31) | 371 (49.20) | 0.57 | 420 (51.72) | 391 (51.52) | 373 (49.01) | 0.50 |
| Smoking | 259 (31.90) | 256 (33.42) | 275 (36.47) | 0.15 | 259 (31.90) | 252 (33.2) | 279 (36.66) | 0.12 |
| Alcohol drinking | 45 (5.54) | 51 (6.66) | 53 (7.03) | 0.45 | 45 (5.54) | 51 (6.72) | 53 (6.96) | 0.46 |
| Biochemical markers | ||||||||
| FPG (mg/dL) | 133.85±42.99 | 137.83±51.13 | 135.45±43.31 | 0.22 | 133.85±42.99 | 137.23±50.32 | 136.08±44.34 | 0.33 |
| HbA1c (%) | 7.49±1.43 | 7.62±1.60 | 7.49±1.44 | 0.16 | 7.49±1.43 | 7.6±1.59 | 7.51±1.45 | 0.30 |
| Albumin (g/dL) | 4.51±0.24 | 4.52±0.24 | 4.52±0.25 | 0.62 | 4.51±0.24 | 4.52±0.24 | 4.53±0.25 | 0.61 |
| Creatinine (mg/dL) | 0.8±0.66 | 0.78±0.44 | 0.79±0.42 | 0.73 | 0.8±0.66 | 0.78±0.44 | 0.79±0.41 | 0.74 |
| Uric acid (mg/dL) | 5.62±1.39 | 5.72±1.46 | 5.72±1.45 | 0.27 | 5.62±1.39 | 5.71±1.46 | 5.72±1.45 | 0.27 |
| ACR (mg/g cr) | 134.47±570.18 | 125.31±560.92 | 117.28±416.86 | 0.81 | 134.47±570.18 | 126.27±563.41 | 116.39±415.04 | 0.79 |
| Triglyceride (mg/dL) | 149.01±105.99 | 159.37±153.51 | 148.69±100.26 | 0.15 | 149.01±105.99 | 159.74±154.13 | 148.43±99.9 | 0.12 |
| Total cholesterol (mg/dL) | 177.49±36.37 | 181.8±37.27 | 176.9±37.4 | 0.02 | 177.49±36.37 | 181.63±37.23 | 177.1±37.46 | 0.03 |
| HDL-C (mg/dL) | 48.72±12.27 | 48.13±12.05 | 48.55±11.59 | 0.61 | 48.72±12.27 | 48.14±12.04 | 48.54±11.6 | 0.62 |
| LDL-C (mg/dL) | 104.71±30.91 | 107.84±30.98 | 103.74±31.73 | 0.03 | 104.71±30.91 | 107.58±30.88 | 104.03±31.84 | 0.06 |
| Disease history | ||||||||
| Obesity (BMI ≥27 kg/m2) | 300 (36.95) | 281 (36.68) | 272 (36.07) | 0.94 | 300 (36.95) | 279 (36.76) | 274 (36.01) | 0.92 |
| Hypertension | 330 (40.64) | 338 (44.13) | 319 (42.31) | 0.38 | 330 (40.64) | 337 (44.4) | 320 (42.05) | 0.32 |
| Hyperlipidemia | 241 (29.68) | 237 (30.94) | 276 (36.60) | 0.008 | 241 (29.68) | 235 (30.96) | 278 (36.53) | 0.009 |
| Heart disease | 131 (16.13) | 114 (14.88) | 125 (16.58) | 0.64 | 131 (16.13) | 113 (14.89) | 126 (16.56) | 0.65 |
| Stroke | 21 (2.59) | 22 (2.87) | 15 (1.99) | 0.53 | 21 (2.59) | 22 (2.90) | 15 (1.97) | 0.50 |
Data were presented as mean±SD for continuous variables or n (%) for categorical variables.
ACR, albumin-to-creatinine ratio; BMI, body mass index; BUN, blood urea nitrogen; FPG, fasting plasma glucose; HDL-C, high density lipoprotein-cholesterol; hsCRP, high-sensitivity C-reactive protein; LDL-C, low density lipoprotein-cholesterol.