Event=renal composite endpoint | |||
Number of event/n | Univariate HR (95% CI) | Multivariate HR (95% CI) | |
FCP tertiles | 89/828 | ||
<1.00 | 33/270 | 1 (ref) | 1 (ref) |
1.00–1.80 | 30/275 | 0.95 (0.58 to 1.55) | 1.20 (0.70 to 2.05) |
>1.80 | 26/283 | 0.86 (0.51 to 1.43) | 1.19 (0.64 to 2.21) |
FCGR tertiles | 89/828 | ||
<0.68 | 43/273 | 1 (ref) | 1 (ref) |
0.68–1.28 | 23/277 | 0.54 (0.33 to 0.90)* | 0.66 (0.38 to 1.15) |
>1.28 | 23/278 | 0.53 (0.32 to 0.89)* | 0.78 (0.41 to 1.50) |
2hPCP tertiles | 95/854 | ||
<2.44 | 51/283 | 1 (ref) | 1 (ref) |
2.44–4.47 | 24/285 | 0.54 (0.33 to 0.88)* | 0.53 (0.31 to 0.92)* |
>4.47 | 20/266 | 0.42 (0.25 to 0.70)† | 0.55 (0.29 to 1.03) |
ΔCP tertiles | 89/828 | ||
<1.20 | 50/276 | 1 (ref) | 1 (ref) |
1.20–2.70 | 20/277 | 0.40 (0.24 to 0.67)† | 0.39 (0.22 to 0.69)† |
>2.70 | 19/275 | 0.36 (0.21 to 0.61)† | 0.43 (0.23 to 0.82)* |
PCGR tertiles | 90/827 | ||
<0.90 | 51/278 | 1 (ref) | 1 (ref) |
0.90–1.85 | 17/273 | 0.38 (0.22 to 0.66)† | 0.44 (0.24 to 0.82)* |
>1.85 | 22/276 | 0.43 (0.26 to 0.71)† | 0.61 (0.31 to 1.20) |
In multivariate analysis, covariates were age, sex, diabetes duration, body mass index, systolic blood pressure, triglyceride, total cholesterol, blood uric acid, eGFR at baseline, urine microalbumin, glycated hemoglobin, fasting blood glucose, and history of insulin treatment.
*P<0.05
†P<0.01
eGFR, estimated glomerular filtration rate; FCGR, fasting C-peptide-to-glucose ratio; FCP, fasting C-peptide; 2hPCP, 2-hour postprandial C-peptide; PCGR, 2-hour postprandial C-peptide-to-glucose ratio; ΔCP, difference between 2-hour postprandial and fasting C-peptide.