The association of the CDKAL1 gene polymorphism with GDM
| SNPs | Genotypes/allele | GDM (%) | Non-GDM (%) | Crud OR (95% CI) | Crud p values | Adjusted OR (95 % CI) | Adjusted p values |
| rs10440833 | TT | 280 (34.53) | 336 (39.53) | 1 (ref.) | 1 (ref.) | ||
| AT | 380 (46.86) | 403 (47.41) | 1.132 (0.916 to 1.398) | 0.253 | 1.098 (0.874 to 1.379) | 0.42 | |
| AA | 151 (18.62) | 111 (13.06) | 1.632 (1.219 to 2.186) | 0.001 | 1.631 (1.192 to 2.232) | 0.002 | |
| rs10946398 | AA | 278 (33.57) | 329 (38.17) | 1 (ref.) | 1 (ref.) | ||
| CA | 400 (48.31) | 411 (47.68) | 1.152 (0.933 to 1.422) | 0.189 | 1.108 (0.884 to 1.390) | 0.372 | |
| CC | 150 (18.12) | 122 (14.15) | 1.382 (1.092 to 1.940) | 0.011 | 1.400 (1.028 to 1.905) | 0.033 | |
| rs4712523 | AA | 270 (32.61) | 323 (37.56) | 1 (ref.) | 1 (ref.) | ||
| GA | 402 (48.55) | 409 (47.56) | 1.176 (0.951 to 1.454) | 0.135 | 1.124 (0.895 to 1.411) | 0.313 | |
| GG | 156 (18.84) | 128 (14.88) | 1.458 (1.097 to 1.937) | 0.009 | 1.409 (1.038 to 1.913) | 0.028 | |
| rs4712524 | AA | 275 (33.21) | 325 (37.75) | 1 (ref.) | 1 (ref.) | ||
| GA | 399 (48.19) | 413 (47.97) | 1.142 (0.924 to 1.411) | 0.219 | 1.090 (0.869 to 1.367) | 0.456 | |
| GG | 154 (18.60) | 123 (14.29) | 1.404 (1.111 to 1.970) | 0.007 | 1.418 (1.043 to 1.929) | 0.026 | |
| rs7754840 | GG | 275 (33.17) | 326 (37.69) | 1 (ref.) | 1 (ref.) | ||
| CG | 399 (48.13) | 415 (47.98) | 1.140 (0.923 to 1.408) | 0.225 | 1.090 (0.869 to 1.367) | 0.456 | |
| CC | 155 (18.70) | 124 (14.34) | 1.482 (1.114 to 1.971) | 0.007 | 1.407 (1.036 to 1.911) | 0.029 | |
| rs7756992 | AA | 199 (24.27) | 231 (26.95) | 1 (ref.) | 1 (ref.) | ||
| GA | 410 (50.00) | 438 (51.11) | 1.087 (0.861 to 1.371) | 0.484 | 1.078 (0.840 to 1.384) | 0.554 | |
| GG | 211 (25.73) | 188 (21.94) | 1.303 (0.991 to 1.712) | 0.058 | 1.272 (0.949 to 1.704) | 0.108 | |
| rs9465871 | TT | 189 (22.77) | 224 (26.02) | 1 (ref.) | 1 (ref.) | ||
| CT | 422 (50.84) | 443 (51.45) | 1.129 (0.893 to 1.428) | 0.312 | 1.066 (0.829 to 1.372) | 0.618 | |
| CC | 219 (26.39) | 194 (22.53) | 1.338 (1.018 to 1.759) | 0.037 | 1.276 (0.952 to 1.711) | 0.103 |
Adjusted OR is adjusted for age, prepregnancy BMI, parity, family history of T2DM.
BMI, body mass index; GDM, gestational diabetes mellitus; ref, reference genotype; SNPs, single nucleotide polymorphisms; T2DM, type 2 diabetes mellitus.