Adjusted odds ratio (95% CIs) of elevated hs-CRP associated with CVD risk factors among adolescents, 2015–2020 NHANES
| OR (95% CI) for elevated hs-CRP | ||
| Low/average risk (≤3.0 mg/L) | High risk (>3.0 mg/L) | |
| Obesity | ||
| Unadjusted | 1.00 | 6.10 (4.62, 8.06) |
| Multivariable model 1* | 1.00 | 6.58 (4.90, 8.83) |
| Multivariable model 2† | 1.00 | 6.64 (4.90, 9.01) |
| Multivariable model 3‡ | 1.00 | 6.39 (4.64, 8.79) |
| Overweight | ||
| Unadjusted | 1.00 | 1.82 (1.12, 2.95) |
| Multivariable model 1* | 1.00 | 1.82 (1.14, 2.90) |
| Multivariable model 2† | 1.00 | 1.85 (1.13, 3.02) |
| Multivariable model 3‡ | 1.00 | 1.87 (1.12, 3.14) |
| A1c≥5.7% (≥39 mmol/mol) | ||
| Unadjusted | 1.00 | 2.46 (1.67, 3.63) |
| Multivariable model 1* | 1.00 | 2.52 (1.63, 3.90) |
| Multivariable model 2† | 1.00 | 2.17 (1.35, 3.49) |
| Multivariable model 3‡ | 1.00 | 1.79 (1.05, 3.06) |
| FPG≥100 mg/dL | ||
| Unadjusted | 1.00 | 1.07 (0.67, 1.71) |
| Multivariable model 1* | 1.00 | 1.28 (0.79, 2.06) |
| Multivariable model 2† | 1.00 | 1.22 (0.75, 1.98) |
| Multivariable model 3‡ | 1.00 | 0.89 (0.49, 1.62) |
| Hypertension | ||
| Unadjusted | 1.00 | 2.30 (1.05, 5.03) |
| Multivariable model 1* | 1.00 | 2.62 (1.22, 5.64) |
| Multivariable model 2† | 1.00 | 2.46 (1.08, 5.60) |
| Multivariable model 3‡ | 1.00 | 1.56 (0.59, 4.14) |
| Hyperlipidemia§ | ||
| Unadjusted | 1.00 | 2.61 (1.65, 4.13) |
| Multivariable model 1* | 1.00 | 2.52 (1.62, 3.94) |
| Multivariable model 2† | 1.00 | 2.19 (1.36, 3.54) |
| Multivariable model 3‡ | 1.00 | 1.55 (0.85, 2.80) |
| Total cholesterol≥170 mg/dL | ||
| Unadjusted | 1.00 | 1.62 (1.22, 2.15) |
| Multivariable model 1* | 1.00 | 1.46 (1.09, 1.95) |
| Multivariable model 2† | 1.00 | 1.40 (1.03, 1.92) |
| Multivariable model 3‡ | 1.00 | 1.20 (0.83, 1.73) |
*Multivariable model 1 adjusted for age, race/ethnicity and sex (demographics).
†Multivariable model 2 additionally adjusted for poverty income ratio, food security (other social determinants of health).
‡Multivariable model 3 additionally adjusted for: Obesity: additionally adjusted for A1c≥5.7% (≥39 mmol/mol), hypertension, total cholesterol. Hyperlipidemia is defined as any elevated cholesterol marker (total, LDL, HDL or triglyceride); fasting sample. Overweight: additionally adjusted for A1c≥5.7% (≥39 mmol/mol), hypertension, total cholesterol. A1c ≥5.7% (≥39 mmol/mol): additionally adjusted for obesity, overweight, hypertension, total cholesterol. FPG ≥100 mg/dL: additionally adjusted for obesity, overweight, hypertension, total cholesterol. Hypertension: additionally adjusted for obesity, overweight, A1c≥5.7% (≥39 mmol/mol), total cholesterol. Hyperlipidemia: additionally adjusted for obesity, overweight, A1c≥5.7% (≥39 mmol/mol), hypertension. Total cholesterol: additionally adjusted for obesity, overweight, A1c≥5.7% (≥39 mmol/mol), hypertension.
§Hyperlipidemia is defined as any elevated cholesterol marker (total, LDL, HDL or triglyceride); fasting sample.
CRP, C reactive protein; CVD, cardiovascular disease; FPG, fasting plasma glucose; HDL, high-density lipoprotein; hs-CRP, high-sensitivity CRP; LDL, low-density lipoprotein; NHANES, National Health and Nutrition Examination Survey.