ROC curve analysis of ISM1 for the diagnosis of different diseases
| Diseases | Cut-off point | AUC | Sensitivity | Specificity | 95% CI |
| MetS | 0.895 | 0.650 | 0.720 | 0.568 | (0.563, 0.736) |
| MetS | ISM1+UA+TG | 0.832 | 0.653 | 0.914 | (0.767, 0.896) |
| MAFLD | 0.970 | 0.642 | 0.610 | 0.667 | (0.517, 0.768) |
| MAFLD | ISM1+UA+TG | 0.930 | 0.829 | 0.912 | (0.872, 0.987) |
ISM1, isthmin-1; MAFLD, metabolic dysfunction associated fatty liver disease; MetS, metabolic syndrome; TG, triglycerides; UA, uric acid.