Characteristics of controls, patients with MAFLD, patients with T2DM and patients with T2DM who have MAFLD
| Controls | MAFLD | T2DM | T2DM with MAFLD | |
| N | 70 | 60 | 60 | 60 |
| Sex (male/female) | 36/34 | 35/25 | 31/29 | 33/27 |
| Age (year) | 46 (33.75, 53.75) | 34 (26, 47) | 57 (49, 63)* † | 55 (43, 62.25)* † |
| BMI (kg/m2) | 21.98±2.65 | 27.58±3.96* | 23.67±2.57* † | 24.33±2.37* † |
| SBP (mm Hg) | 116.35±15.16 | 126.68±14.74* | 127.72±13.84* | 130.4±13.1* |
| DBP (mm Hg) | 71.5 (65, 80) | 72 (68.5, 80) | 78(70, 87)* † | 81.5 (74.5, 92)* † |
| UA (umol/L) | 291.63±56.37 | 393.68±108.41* | 300.47±88.88† | 348.52±95.45* † ‡ |
| ALT (U/L) | 18 (13.5, 26.25) | 28 (18, 44)* | 23 (18, 39)* | 27 (20, 40)* |
| AST (U/L) | 21 (17, 24.25) | 23 (18.5, 30.5) | 23 (18, 30) | 23 (18.75, 29.25) |
| TG (mmol/L) | 1.01 (0.87,1.27) | 1.71 (1.19, 2.87)* | 1.42 (1.18, 1.9)* | 2.05 (1.54, 3.43)* ‡ |
| TC (mmol/L) | 4.49±0.7 | 4.99±1.17* | 5.06±1.18* | 5.34±1.18* |
| HDL (mmol/L) | 1.39 (1.25, 1.68) | 1.17 (1.03, 1.44)* | 1.26 (1.13, 1.43)* | 1.27 (1.06, 1.49)* |
| LDL (mmol/L) | 2.26±0.78 | 2.93±0.92* | 3.05±0.93* | 3.09±0.85* |
| WBCs (×109/L) | 5.48 (4.56, 6.73) | 6.96 (5.92, 7.7)* | 6.09 (5.33, 7.48)* | 7.1 (6.06, 8.16)* ‡ |
| HbA1c (%) | 5.2 (5, 5.5) | 5.4 (5.15, 5.7) | 8.3 (6.9, 11.2)* † | 8.35 (7.28, 9.83)* † |
| FBG (mmol/L) | 4.82 (4.58, 5.2) | 5.17 (4.79, 5.55) | 8.39 (6.8, 10.38)* † | 7.92 (6.99, 8.95)* † |
| FINS (mU/L) | 7.57 (6.06, 9.9) | 15.55 (9.66, 25.12)* | 9.59 (6.98, 15.14)* † | 11.59 (6.85, 17.04)* † |
| HOMA-IR | 1.66 (1.32, 2.15) | 3.51 (2.11, 5.79)* | 3.82 (2.22, 6.02)* | 4 (2.58, 5.81)* |
Data are shown as the mean±SD or median (IQR).
*P<0.05 vs controls.
†P<0.05 vs MAFLD.
‡P<0.05 vs T2DM.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; DBP, diastolic blood pressure; FBG, fasting blood glucose; FINS, fasting insulin; HbA1c, glycosylated hemoglobin; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; LDL-C, low-density lipoprotein cholesterol; MAFLD, metabolic dysfunction associated fatty liver disease; SBP, systolic blood pressure; TC, total cholesterol; T2DM, type 2 diabetes mellitus; TG, triglycerides; UA, uric acid; WBCs, white blood cells.